ReferenceID 2832
Scoparone alleviates hepatic fibrosis by inhibiting the TLR-4/NF-κB pathway
J Cell Physiol
The aim of this study was to investigate the role of scoparone (SCO) in hepatic fibrosis. For this, we conducted in vivo and in vitro experiments. In vivo rats that were divided into six groups, control, carbon tetrachlo
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Record Fields
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- Reference Id
- 2832
- Evidence Id
- 19422
- Core Evidence Id
- 19422
- Source Reference Id
- 5655
- Herb2 Reference Id
- HBREF006452
- Subject Paper Key
- HBIN043437_33090488
- Pubmed Id
- 33090488
- Doi
- 10.1002/jcp.30083
- Paper Title
- Scoparone alleviates hepatic fibrosis by inhibiting the TLR-4/NF-κB pathway
- Paper Abstract
- The aim of this study was to investigate the role of scoparone (SCO) in hepatic fibrosis. For this, we conducted in vivo and in vitro experiments. In vivo rats that were divided into six groups, control, carbon tetrachloride, and colchicine, as well as SCO groups, SCO50, SCO100, and SCO200 treated with 50, 100, and 200 mg/kg SCO doses, respectively. Furthermore, SCO was shown to inhibit Toll-like receptor-4 (TLR-4)/nuclear factor kappa-B (NF-kappaB; TLR-4/NF-kappaB) signals by inhibiting TLR-4, which in turn downregulates the expression of MyD88, promotes NF-kappaB inhibitor-alpha, NF-kappaB inhibitor-beta, and NF-kappaB inhibitor-epsilon activation, while inhibiting NF-kappaB inhibitor-zeta. Subsequently, the decrease of phosphorylation of nuclear factor-kappaB levels leads to the downregulation of the downstream inflammatory factors' tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and IL-1 beta, thus weakening hepatic fibrosis. Notably, the SCO200 treated group presented the most significant improvement. Hence, we conclude that SCO alleviates hepatic fibrosis by inhibiting TLR-4/NF-kappaB signals.
- Journal
- J Cell Physiol
- Publish Year
- 2020
- Experiment Subject
- rat
- Experiment Type
- Cell Experiment
- Phenotype Related
- Tumor; Hepatic Fibrosis
- Paper Title Cn
- Paper Title En
- Scoparone alleviates hepatic fibrosis by inhibiting the TLR-4/NF-κB pathway
- Bilingual Status
- semi_complete