ReferenceID 2826
Sarsasapogenin attenuates Alzheimer-like encephalopathy in diabetes
Phytomedicine
BACKGROUND: A crosstalk exists between diabetes and Alzheimer's disease (AD), and diabetic encephalopathy displays AD-like disorders. Sarsasapogenin (Sar) has strong anti-inflammatory efficacy, showing neuroprotection an
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Record Fields
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- Reference Id
- 2826
- Evidence Id
- 19416
- Core Evidence Id
- 19416
- Source Reference Id
- 5649
- Herb2 Reference Id
- HBREF006446
- Subject Paper Key
- HBIN043195_34333330
- Pubmed Id
- 34333330
- Doi
- 10.1016/j.phymed.2021.153686
- Paper Title
- Sarsasapogenin attenuates Alzheimer-like encephalopathy in diabetes
- Paper Abstract
- BACKGROUND: A crosstalk exists between diabetes and Alzheimer's disease (AD), and diabetic encephalopathy displays AD-like disorders. Sarsasapogenin (Sar) has strong anti-inflammatory efficacy, showing neuroprotection and memory-enhancement effects. PURPOSE: This study aims to verify the ameliorative effects of Sar on diabetic encephalopathy in vivo and in vitro, and to clarify the mechanisms from attenuation of AD-like pathology. METHODS: Streptozotocin-induced type 1 diabetic rats and high glucose-cultured SH-SY5Y cells were used in this study. After Sar treatment (20 and 60 mg/kg) for consecutive 9 weeks, Morris water maze and novel object recognition tasks were performed. Hematoxylin-eosin staining was used for examining loss of neurons in CA1 area and ki67 expression for reflecting neurogenesis in DG area of hippocampus. Abeta production pathway and tau phosphorylation kinase cascade were examined in these two models. RESULTS: Sar improved learning and memory ability, loss of neurons and reduction of neurogenesis in the hippocampus of diabetic rats. Moreover, Sar suppressed Abeta overproduction due to up-regulation of BACE1 in protein and mRNA and tau hyperphosphorylation from inactivation of AKT/GSK-3beta cascade in the hippocampus and cerebral cortex of diabetic rats and high glucose-cultured SH-SY5Y cells, and PPARgamma antagonism abolished the effects of Sar on key molecules in the two pathways. Additionally, it was found that high glucose-stimulated Abeta overproduction was prior to tau hyperphosphorylation in neurons. CONCLUSION: Sar alleviated diabetic encephalopathy, which was obtained through inhibitions of Abeta overproduction and tau hyperphosphorylation mediated by the activation of PPARgamma signaling. Hence, Sar is a good candidate compound for AD-like disorders.
- Journal
- Phytomedicine
- Publish Year
- 2021
- Experiment Subject
- rat; sh-sy5y cells
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Diabetic Encephalopathy; Alzheimer's Disease; Streptozotocin-induced Type 1 Diabetic; Ad-like Pathology; Diabetic; Ad-like Disorders; Diabetes
- Paper Title Cn
- Paper Title En
- Sarsasapogenin attenuates Alzheimer-like encephalopathy in diabetes
- Bilingual Status
- semi_complete