ReferenceID 2740
Punicalagin Alleviates Psoriasis by Inhibiting NF-κB-Mediated IL-1β Transcription and Caspase-1-Regulated IL-1β Secretion
Front Pharmacol
Psoriasis is a chronic and inflammatory skin disorder characterized by inflammation and epidermal hyperplasia. Punicalagin (PUN) is a main active ingredient of pomegranate ( Punica granatum L.) peel with multiple biologi
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Record Fields
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- Reference Id
- 2740
- Evidence Id
- 19330
- Core Evidence Id
- 19330
- Source Reference Id
- 5469
- Herb2 Reference Id
- HBREF006266
- Subject Paper Key
- HBIN041294_35153790
- Pubmed Id
- 35153790
- Doi
- 10.3389/fphar.2022.817526
- Paper Title
- Punicalagin Alleviates Psoriasis by Inhibiting NF-κB-Mediated IL-1β Transcription and Caspase-1-Regulated IL-1β Secretion
- Paper Abstract
- Psoriasis is a chronic and inflammatory skin disorder characterized by inflammation and epidermal hyperplasia. Punicalagin (PUN) is a main active ingredient of pomegranate ( Punica granatum L.) peel with multiple biological activities, such as antibacterial, antioxidant and anti-tumor effects. However, the potential effect of PUN on psoriasis remains unknown. In this study, we want to investigate the pharmacological effect of PUN on psoriasis by using imiquimod (IMQ)-induced psoriatic mice model in vivo and tumor necrosis factor a (TNF-α) and interleukin-17A (IL-17A)-stimulated HaCaT cells in vitro . Our results showed that PUN can effectively alleviate the severity of psoriasis-like symptoms. Mechanistically, PUN potently suppresses the aberrant upregulation of interleukin-1β (IL-1β) and subsequent IL-1β-mediated inflammatory cascade in keratinocytes by inhibiting the nuclear factor kappa B (NF-κB) activation and cleaved caspase-1 expression in vitro and in vivo . Taken together, our findings indicate that PUN can relieve psoriasis by repressing NF-κB-mediated IL-1β transcription and caspase-1-regulated IL-1β secretion, which provide evidence that PUN might represent a novel and promising candidate for the treatment of psoriasis.
- Journal
- Front Pharmacol
- Publish Year
- 2022
- Experiment Subject
- mouse; interleukin-17a (il-17a)-stimulated hacat cells; pomegranate
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Inflammation; Epidermal Hyperplasia; Tumor; Psoriasis; Chronic And Inflammatory Skin Disorder
- Paper Title Cn
- Paper Title En
- Punicalagin Alleviates Psoriasis by Inhibiting NF-κB-Mediated IL-1β Transcription and Caspase-1-Regulated IL-1β Secretion
- Bilingual Status
- semi_complete