ReferenceID 2695
Protocatechuic acid protects mice from influenza A virus infection
Eur J Clin Microbiol Infect Dis
Influenza A virus (IAV) H1N1 infection remains great challenge to public health and causes great burden over the world. Although there are anti-viral agents available, searching for effective agents to treat H1N1 infecti
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- Reference Id
- 2695
- Evidence Id
- 19285
- Core Evidence Id
- 19285
- Source Reference Id
- 5388
- Herb2 Reference Id
- HBREF006185
- Subject Paper Key
- HBIN040908_35067799
- Pubmed Id
- 35067799
- Doi
- 10.1007/s10096-022-04401-y
- Paper Title
- Protocatechuic acid protects mice from influenza A virus infection
- Paper Abstract
- Influenza A virus (IAV) H1N1 infection remains great challenge to public health and causes great burden over the world. Although there are anti-viral agents available, searching for effective agents to treat H1N1 infection is still in urgent because of the emergence of resistant strain. Protocatechuic acid (PCA) is a biological agent with multiple functions. In present study, we explored the effects of PCA on H1N1 infection. Mice infected with mouse adapted influenza strain A/Font Monmouth were administrated with PCA. The body weight change, mortality, lung index, viral titer, immune cell infiltration, and cytokine production in the lung were monitored. The activation of toll-like receptor 4 (TLR4) and nuclear factor kappa light chain enhancer of activated B cells (NF-κB) pathway was investigated. PCA treatment prevented H1N1 infection-induced mice body weight loss and death. PCA reduced the lung index, viral titer, infiltration of immune cells, and cytokine level in the lung, as well as suppressed H1N1-induced TLR4/NF-κB activation. PCA protects mice against H1N1 infection and could be a potential therapeutic agent to treat influenza.
- Journal
- Eur J Clin Microbiol Infect Dis
- Publish Year
- 2022
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Influenza; Influenza A Virus
- Paper Title Cn
- Paper Title En
- Protocatechuic acid protects mice from influenza A virus infection
- Bilingual Status
- semi_complete