ReferenceID 2692
Protocatechuic acid inhibits proliferation, migration and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes
Artif Cells Nanomed Biotechnol
Rheumatoid arthritis (RA) is a chronic joint inflammatory disease that is closely associated with dysregulation of fibroblast-like synoviocytes (FLSs). Protocatechuic acid (PCA), a phenolic compound of anthocyanins, has
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Record Fields
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- Reference Id
- 2692
- Evidence Id
- 19282
- Core Evidence Id
- 19282
- Source Reference Id
- 5381
- Herb2 Reference Id
- HBREF006178
- Subject Paper Key
- HBIN040908_32510258
- Pubmed Id
- 32510258
- Doi
- 10.1080/21691401.2020.1776307
- Paper Title
- Protocatechuic acid inhibits proliferation, migration and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes
- Paper Abstract
- Rheumatoid arthritis (RA) is a chronic joint inflammatory disease that is closely associated with dysregulation of fibroblast-like synoviocytes (FLSs). Protocatechuic acid (PCA), a phenolic compound of anthocyanins, has been proven to possess anti-inflammatory activity. However, the role of PCA in RA has not been investigated. In the present study, we aimed to explore the effects of PCA on the RA-FLSs. The results showed that PCA suppressed the proliferation, invasion, and migration of RA-FLSs in a dose-dependent manner. PCA treatment also inhibited the expressions of matrix metalloproteinase (MMP)-3 and MMP-13, as well as the secretion of inflammatory cytokines including TNF-alpha, IL-1beta, IL-6 in RA-FLSs. Moreover, cell apoptosis of RA-FLSs was significantly induced by PCA treatment. PCA was found to repress the activation of NF-kappaB signalling, which was evidenced by the decreased expression of p-p65 and increased expression of IkappaBalpha. Furthermore, PCA significantly decreased the phosphorylation levels of Akt and mTOR in RA-FLSs. In conclusion, the results indicated that PCA exhibited an inhibitory effect on RA-FLSs via inhibiting the NF-kappaB and Akt/mTOR signalling pathways. These findings supported the concept that PCA might be a therapeutic agent for RA treatment.
- Journal
- Artif Cells Nanomed Biotechnol
- Publish Year
- 2020
- Experiment Subject
- Experiment Type
- Cell Experiment
- Phenotype Related
- Rheumatoid Arthritis; Chronic Joint Inflammatory Disease
- Paper Title Cn
- Paper Title En
- Protocatechuic acid inhibits proliferation, migration and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes
- Bilingual Status
- semi_complete