ReferenceID 2652
Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer Via Downregulation of Nuclear p65 and HIF-1α
Cancers (Basel)
Piceatannol (PIC) is known to have anticancer activity, which has been attributed to its ability to block the proliferation of cancer cells via suppression of the NF-kB signaling pathway. However, its effect on hypoxia-i
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Record Fields
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- Reference Id
- 2652
- Evidence Id
- 19242
- Core Evidence Id
- 19242
- Source Reference Id
- 5303
- Herb2 Reference Id
- HBREF006100
- Subject Paper Key
- HBIN040152_31906321
- Pubmed Id
- 31906321
- Doi
- 10.3390/cancers12010113
- Paper Title
- Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer Via Downregulation of Nuclear p65 and HIF-1α
- Paper Abstract
- Piceatannol (PIC) is known to have anticancer activity, which has been attributed to its ability to block the proliferation of cancer cells via suppression of the NF-kB signaling pathway. However, its effect on hypoxia-inducible factor (HIF) is not well known in cancer. In this study, PIC was loaded into bovine serum albumin (BSA) by desolvation method as PIC-BSA nanoparticles (NPs). These PIC-BSA nanoparticles were assessed for in vitro cytotoxicity, migration, invasion, and colony formation studies and levels of p65 and HIF-1alpha. Our results indicate that PIC-BSA NPs were more effective in downregulating the expression of nuclear p65 and HIF-1alpha in colon cancer cells as compared to free PIC. We also observed a significant reduction in inflammation induced by chemical colitis in mice by PIC-BSA NPs. Furthermore, a significant reduction in tumor size and number of colon tumors was also observed in the murine model of colitis-associated colorectal cancer, when treated with PIC-BSA NPs as compared to free PIC. The overall results indicate that PIC, when formulated as PIC-BSA NPs, enhances its therpautice potential. Our work could prompt further research in using natural anticancer agents as nanoparticels with possiable human clinical trails. This could lead to the development of a new line of safe and effective therapeutics for cancer patients.
- Journal
- Cancers (Basel)
- Publish Year
- 2020
- Experiment Subject
- mouse; human; patient; bovine
- Experiment Type
- Animal Experiment
- Phenotype Related
- Colon Cancer; Tumor; Cancer; Colitis-associated Colorectal Cancer; Colon Tumors; Chemical Colitis
- Paper Title Cn
- Paper Title En
- Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer Via Downregulation of Nuclear p65 and HIF-1α
- Bilingual Status
- semi_complete