ReferenceID 2644
Piperlongumine Alleviates Mouse Colitis and Colitis-Associated Colorectal Cancer
Front Pharmacol
Colorectal cancer is one of the most common and lethal cancers in the world. An important causative factor of colorectal cancer is ulcerative colitis. In this study, we investigated the therapeutic effects of piperlongum
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 2644
- Evidence Id
- 19234
- Core Evidence Id
- 19234
- Source Reference Id
- 5293
- Herb2 Reference Id
- HBREF006090
- Subject Paper Key
- HBIN040107_33343354
- Pubmed Id
- 33343354
- Doi
- 10.3389/fphar.2020.586885
- Paper Title
- Piperlongumine Alleviates Mouse Colitis and Colitis-Associated Colorectal Cancer
- Paper Abstract
- Colorectal cancer is one of the most common and lethal cancers in the world. An important causative factor of colorectal cancer is ulcerative colitis. In this study, we investigated the therapeutic effects of piperlongumine (PL) on the dextran sulfate sodium (DSS)-induced acute colitis and azoxymethane (AOM)/DSS-induced colorectal cancer mouse models. Our results showed that PL could inhibit the inflammation of DSS-induced mouse colitis and reduce the number of large neoplasms (diameter >2 mm) of AOM/DSS-induced mouse colorectal cancer by downregulation of proinflammatory cytokines cyclooxygenase-2 and interleukin-6 and epithelial-mesenchymal transition-related factors, beta-catenin, and snail expressions, but fail to improve the colitis symptoms and to decrease the incidence of colonic neoplasms and the number of small neoplasms (diameter <2 mm). These data suggested that PL might be an effective agent in treating colitis and colorectal cancer.
- Journal
- Front Pharmacol
- Publish Year
- 2020
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Colonic Neoplasms; Ulcerative Colitis; Cancers; Neoplasms; Colorectal Cancer; Colitis; Acute Colitis
- Paper Title Cn
- Paper Title En
- Piperlongumine Alleviates Mouse Colitis and Colitis-Associated Colorectal Cancer
- Bilingual Status
- semi_complete