ReferenceID 2629
Pinocembrin Promotes OPC Differentiation and Remyelination via the mTOR Signaling Pathway
Neurosci Bull
The exacerbation of progressive multiple sclerosis (MS) is closely associated with obstruction of the differentiation of oligodendrocyte progenitor cells (OPCs). To discover novel therapeutic compounds for enhancing remy
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Record Fields
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- Reference Id
- 2629
- Evidence Id
- 19219
- Core Evidence Id
- 19219
- Source Reference Id
- 5263
- Herb2 Reference Id
- HBREF006060
- Subject Paper Key
- HBIN039998_34091810
- Pubmed Id
- 34091810
- Doi
- 10.1007/s12264-021-00696-7
- Paper Title
- Pinocembrin Promotes OPC Differentiation and Remyelination via the mTOR Signaling Pathway
- Paper Abstract
- The exacerbation of progressive multiple sclerosis (MS) is closely associated with obstruction of the differentiation of oligodendrocyte progenitor cells (OPCs). To discover novel therapeutic compounds for enhancing remyelination by endogenous OPCs, we screened for myelin basic protein expression using cultured rat OPCs and a library of small-molecule compounds. One of the most effective drugs was pinocembrin, which remarkably promoted OPC differentiation and maturation without affecting cell proliferation and survival. Based on these in vitro effects, we further assessed the therapeutic effects of pinocembrin in animal models of demyelinating diseases. We demonstrated that pinocembrin significantly ameliorated the progression of experimental autoimmune encephalomyelitis (EAE) and enhanced the repair of demyelination in lysolectin-induced lesions. Further studies indicated that pinocembrin increased the phosphorylation level of mammalian target of rapamycin (mTOR). Taken together, our results demonstrated that pinocembrin promotes OPC differentiation and remyelination through the phosphorylated mTOR pathway, and suggest a novel therapeutic prospect for this natural flavonoid product in treating demyelinating diseases.
- Journal
- Neurosci Bull
- Publish Year
- 2021
- Experiment Subject
- rat; cultured rat opcs
- Experiment Type
- Cell Experiment
- Phenotype Related
- Autoimmune Encephalomyelitis; Lysolectin-induced Lesions; Progressive Multiple Sclerosis; Demyelination; Demyelinating Diseases
- Paper Title Cn
- Paper Title En
- Pinocembrin Promotes OPC Differentiation and Remyelination via the mTOR Signaling Pathway
- Bilingual Status
- semi_complete