ReferenceID 2627
Phytol loaded PLGA nanoparticles regulate the expression of Alzheimer's related genes and neuronal apoptosis against amyloid-β induced toxicity in Neuro-2a cells and transgenic Caenorhabditis elegans
Food Chem Toxicol
Amyloid beta (Abeta) induced neurotoxicity has been postulated to initiate synaptic loss and subsequent neuronal degeneration in Alzheimer's disease (AD). The nanoparticles based drug carrier system is considered as a pr
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Record Fields
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- Reference Id
- 2627
- Evidence Id
- 19217
- Core Evidence Id
- 19217
- Source Reference Id
- 5254
- Herb2 Reference Id
- HBREF006051
- Subject Paper Key
- HBIN039794_31734340
- Pubmed Id
- 31734340
- Doi
- 10.1016/j.fct.2019.110962
- Paper Title
- Phytol loaded PLGA nanoparticles regulate the expression of Alzheimer's related genes and neuronal apoptosis against amyloid-β induced toxicity in Neuro-2a cells and transgenic Caenorhabditis elegans
- Paper Abstract
- Amyloid beta (Abeta) induced neurotoxicity has been postulated to initiate synaptic loss and subsequent neuronal degeneration in Alzheimer's disease (AD). The nanoparticles based drug carrier system is considered as a promising therapeutic strategy to combat this incurable disease. It was also found to inhibit cholinesterase activity and apoptosis mediated cell death in Neuro-2a cells. The in vivo study further revealed that the Phytol and Phytol-PLGA NPs (Poly Lactic-co-Glycolic Acid Nanoparticles) was found to increase the lifespan, chemotaxis behavior and decrease Abeta deposition & ROS (Reactive oxygen species) production in transgenic Caenorhabditis elegans models of AD (CL2006, CL4176). Phytol and Phytol-PLGA NPs treatment downregulated the expression of AD associated genes viz Abeta, ace-1 and hsp-4 and upregulated the gene involved in the longevity to nematodes (dnj-14) and it also reduced the expression of Abeta peptide at the protein level. Our results of in vitro and in vivo studies suggest that Phytol and Phytol-PLGA NPs hold promising neuroprotective efficacy and targets multiple neurotoxic mechanisms involved in the AD progression.
- Journal
- Food Chem Toxicol
- Publish Year
- 2020
- Experiment Subject
- neuro-2a cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Neuronal Degeneration; Incurable Disease; Alzheimer's Disease
- Paper Title Cn
- Paper Title En
- Phytol loaded PLGA nanoparticles regulate the expression of Alzheimer's related genes and neuronal apoptosis against amyloid-β induced toxicity in Neuro-2a cells and transgenic Caenorhabditis elegans
- Bilingual Status
- semi_complete