ReferenceID 2563
Oxytocin suppresses epithelial cell-derived cytokines production and alleviates intestinal inflammation in food allergy
Biochem Pharmacol
Food allergy is a growing healthcare problem worldwide, but prophylactic options and regulatory therapies are limited. Oxytocin (OXT), conventionally acknowledged as a hormone, was recently proven to have potent anti-inf
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- Reference Id
- 2563
- Evidence Id
- 19153
- Core Evidence Id
- 19153
- Source Reference Id
- 5128
- Herb2 Reference Id
- HBREF005925
- Subject Paper Key
- HBIN038531_34863977
- Pubmed Id
- 34863977
- Doi
- 10.1016/j.bcp.2021.114867
- Paper Title
- Oxytocin suppresses epithelial cell-derived cytokines production and alleviates intestinal inflammation in food allergy
- Paper Abstract
- Food allergy is a growing healthcare problem worldwide, but prophylactic options and regulatory therapies are limited. Oxytocin (OXT), conventionally acknowledged as a hormone, was recently proven to have potent anti-inflammatory and immunomodulatory activities in certain diseases. Here, we reported the novel function and its underlying mechanisms of OXT on food allergy in vivo and in vitro. We showed that the levels of OXT were elevated in ovalbumin (OVA)-allergic mice and patients with food allergy. In HT-29 cells, OXT inhibited the production of the epithelial cell-derived cytokines thymic stromal lymphopoietin (TSLP), interleukin (IL)-25 and IL-33 by suppressing NF-kappaB signaling, in which beta-arrestin2 participated. These functions of OXT were abolished by oxytocin receptor (OXTR) depletion. Treating OVA-induced BALB/c mice with OXT suppressed TSLP, IL-25 and IL-33 production and attenuated systemic anaphylaxis and intestinal inflammation. OXTR-/- mice showed extreme increases in TSLP, IL-25 and IL-33 levels as well as severe systemic anaphylaxis and intestinal inflammation. In conclusion, through OXTRs, OXT has a promising antiallergic effect on experimental food allergy by suppressing epithelial TSLP, IL-25 and IL-33 production by inhibiting NF-kappaB signaling and upregulating beta-arrestin2 expression. Our study provides a new therapeutic perspective for food allergy in humans.
- Journal
- Biochem Pharmacol
- Publish Year
- 2022
- Experiment Subject
- mouse; human; patient; ht-29 cells
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Food Allergy; Systemic Anaphylaxis; Attenuated Systemic Anaphylaxis; Intestinal Inflammation
- Paper Title Cn
- Paper Title En
- Oxytocin suppresses epithelial cell-derived cytokines production and alleviates intestinal inflammation in food allergy
- Bilingual Status
- semi_complete