ReferenceID 2556
Oxymatrine Inhibits Renal Cell Carcinoma Progression by Suppressing β-Catenin Expression
Front Pharmacol
Aims: Oxymatrine (OMT) has been identified to possess immunomodulatory, antiinflammatory and anticancer properties. This study aimed to investigate its precise function and the underlying molecular mechanisms in renal ce
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Record Fields
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- Reference Id
- 2556
- Evidence Id
- 19146
- Core Evidence Id
- 19146
- Source Reference Id
- 5117
- Herb2 Reference Id
- HBREF005914
- Subject Paper Key
- HBIN038488_32581789
- Pubmed Id
- 32581789
- Doi
- 10.3389/fphar.2020.00808
- Paper Title
- Oxymatrine Inhibits Renal Cell Carcinoma Progression by Suppressing β-Catenin Expression
- Paper Abstract
- Aims: Oxymatrine (OMT) has been identified to possess immunomodulatory, antiinflammatory and anticancer properties. This study aimed to investigate its precise function and the underlying molecular mechanisms in renal cell carcinoma progression. Methods: The antineoplastic effect of oxymatrine was investigated by CCK-8 assay, cell cycle analysis, apoptosis assay, wound healing experiment, transwell assay, and drug-sensitivity analysis in renal cancer cells following oxymatrine treatment. The modulation of oxymatrine on beta-catenin was analyzed through western blot and immunofluorescence assay. beta-catenin overexpression was employed to determine the key role of beta-catenin in oxymatrine-inhibited renal cell carcinoma in vitro. In addition, animal model was established to investigate the effect of oxymatrine on tumor growth in vivo. Results: Oxymatrine inhibited renal cell carcinoma progression in vitro, including cell proliferation, apoptosis, migration, invasion and chemotherapy sensitivity. Further mechanistic studies demonstrated that oxymatrine exerted its antineoplastic effect through suppressing the expression of beta-catenin. Moreover, in nude mice model, oxymatrine exhibited remarkable inhibition of tumor growth, which was consistent with our in vitro results. Conclusions: Our findings illuminate oxymatrine as an effective antitumor agent in renal cell carcinoma, and suggest it a promising therapeutic application in renal cell carcinoma treatment.
- Journal
- Front Pharmacol
- Publish Year
- 2020
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Renal Cell Carcinoma; Tumor; Renal Cancer
- Paper Title Cn
- Paper Title En
- Oxymatrine Inhibits Renal Cell Carcinoma Progression by Suppressing β-Catenin Expression
- Bilingual Status
- semi_complete