ReferenceID 2550
Effects of Osthole on Inflammatory Gene Expression and Cytokine Secretion in Histamine-Induced Inflammation in the Caco-2 Cell Line
Int J Mol Sci
Hyperactivity of the immune system in the gastrointestinal tract leads to the development of chronic, inflammation-associated disorders. Such diseases, including inflammatory bowel disease, are not completely curable, bu
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 2550
- Evidence Id
- 19140
- Core Evidence Id
- 19140
- Source Reference Id
- 5108
- Herb2 Reference Id
- HBREF005905
- Subject Paper Key
- HBIN038387_34948440
- Pubmed Id
- 34948440
- Doi
- 10.3390/ijms222413634
- Paper Title
- Effects of Osthole on Inflammatory Gene Expression and Cytokine Secretion in Histamine-Induced Inflammation in the Caco-2 Cell Line
- Paper Abstract
- Hyperactivity of the immune system in the gastrointestinal tract leads to the development of chronic, inflammation-associated disorders. Such diseases, including inflammatory bowel disease, are not completely curable, but the specific line of treatment may reduce its symptoms. However, the response to treatment varies among patients, creating a necessity to uncover the pathophysiological basis of immune-mediated diseases and apply novel therapeutic strategies. The present study describes the anti-inflammatory properties of osthole during histamine-induced inflammation in the intestinal Caco-2 cell line. Osthole reduced the secretion of cytokines (CKs) and the expression level of inflammation-associated genes, which were increased after a histamine treatment. We have shown that the secretion of pro-inflammatory CKs (IL-1beta, IL-6, IL-8, and TNF-alpha) during inflammation may be mediated by NFkappaB, and, after osthole treatment, this signaling pathway was disrupted. Our results suggest a possible role for osthole in the protection against inflammation in the gastrointestinal tract; thus, osthole may be considered as an anti-inflammatory modulator.
- Journal
- Int J Mol Sci
- Publish Year
- 2021
- Experiment Subject
- patient; intestinal caco-2 cell line
- Experiment Type
- Cell Experiment
- Phenotype Related
- Inflammatory Bowel Disease; Immune-mediated Diseases; Chronic, Inflammation-associated Disorders; Inflammation
- Paper Title Cn
- Paper Title En
- Effects of Osthole on Inflammatory Gene Expression and Cytokine Secretion in Histamine-Induced Inflammation in the Caco-2 Cell Line
- Bilingual Status
- semi_complete