ReferenceID 2537
Orientin reduces the inhibitory effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipogenic differentiation and insulin signaling pathway in murine 3T3-L1 adipocytes
Chem Biol Interact
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) accumulates in human body, probably influencing adipocyte differentiation and causing various toxic effects, including wasting syndrome. Recently, orientin, a phenolic compound
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 2537
- Evidence Id
- 19127
- Core Evidence Id
- 19127
- Source Reference Id
- 5083
- Herb2 Reference Id
- HBREF005880
- Subject Paper Key
- HBIN038267_32044341
- Pubmed Id
- 32044341
- Doi
- 10.1016/j.cbi.2020.108978
- Paper Title
- Orientin reduces the inhibitory effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipogenic differentiation and insulin signaling pathway in murine 3T3-L1 adipocytes
- Paper Abstract
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) accumulates in human body, probably influencing adipocyte differentiation and causing various toxic effects, including wasting syndrome. Recently, orientin, a phenolic compound abundant in natural health products, has been shown to have antioxidant properties. We investigated the protective effects of orientin against TCDD-induced adipocyte dysfunction and its underlying mechanisms. In this study, orientin suppressed TCDD-induced loss of lipid accumulation. Orientin inhibited TCDD-driven decreases in the levels of peroxisome proliferator-activated receptor gamma and adiponectin. Orientin also reduced TCDD-induced prostaglandin E2, and cytosolic phospholipase A2alpha levels, and increased TCDD-inhibited peroxisome proliferator-activated receptor gamma coactivator 1-alpha levels in 3T3-L1 adipocytes. TCDD reduced the levels of insulin receptor substrate 1 and glucose transporter 4, and decreased insulin-stimulated glucose uptake activity; however, orientin diminished these TCDD-induced effects. These results suggest that orientin may have beneficial effects on the prevention of TCDD-induced wasting syndrome and type II diabetes mellitus accompanied by insulin resistance.
- Journal
- Chem Biol Interact
- Publish Year
- 2020
- Experiment Subject
- human; 3t3-l1 adipocytes
- Experiment Type
- Cell Experiment
- Phenotype Related
- Adipocyte Dysfunction; Tcdd-induced Wasting Syndrome; Wasting Syndrome; Type Ii Diabetes Mellitus
- Paper Title Cn
- Paper Title En
- Orientin reduces the inhibitory effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipogenic differentiation and insulin signaling pathway in murine 3T3-L1 adipocytes
- Bilingual Status
- semi_complete