ReferenceID 2479
Nepetin inhibits osteoclastogenesis by inhibiting RANKL-induced activation of NF-κB and MAPK signalling pathway, and autophagy
J Cell Mol Med
Aseptic prosthetic loosening due to wear particle-induced inflammatory osteolysis is the main cause of failure for artificial joint replacement. The inflammatory response and the production of pro-osteoclastic factors le
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Record Fields
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- Reference Id
- 2479
- Evidence Id
- 19069
- Core Evidence Id
- 19069
- Source Reference Id
- 4981
- Herb2 Reference Id
- HBREF005778
- Subject Paper Key
- HBIN036777_33135301
- Pubmed Id
- 33135301
- Doi
- 10.1111/jcmm.16055
- Paper Title
- Nepetin inhibits osteoclastogenesis by inhibiting RANKL-induced activation of NF-κB and MAPK signalling pathway, and autophagy
- Paper Abstract
- Aseptic prosthetic loosening due to wear particle-induced inflammatory osteolysis is the main cause of failure for artificial joint replacement. The inflammatory response and the production of pro-osteoclastic factors lead to elevation of osteoclast formation and excessive activity results in extensive bone destruction around the bone-implant interface. Here we showed that Nepetin, a natural bioactive flavonoid with proven anti-inflammatory and anti-proliferative properties, potently inhibited RANKL-induced osteoclast differentiation, formation and bone resorption in vitro, and protected mice against the deleterious effects of titanium particle-induced calvarial osteolysis in vivo. Mechanistically, Nepetin attenuated RANKL-induced activation of NF-kappaB and MAPK signalling pathways and TRAF6-dependent ubiquitination of Beclin 1 which is necessary for the induction of autophagy. In brief, our study demonstrates the potential therapeutic application of Nepetin against osteoclast-mediated osteolytic diseases.
- Journal
- J Cell Mol Med
- Publish Year
- 2020
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Osteolytic Diseases; Calvarial Osteolysis; Inflammatory Osteolysis; Failure For Artificial Joint Replacement; Aseptic Prosthetic Loosening
- Paper Title Cn
- Paper Title En
- Nepetin inhibits osteoclastogenesis by inhibiting RANKL-induced activation of NF-κB and MAPK signalling pathway, and autophagy
- Bilingual Status
- semi_complete