ReferenceID 2477
Anti-Postmenopausal osteoporosis effects of Isopsoralen: A bioinformatics-integrated experimental study
Phytother Res
Isopsoralen (IPRN), which comes from the fruit of Psoralea corylifolia, has been identified as a kind of phytoestrogen and has been proven to be effective for the treatment of osteoporosis (OP). However, the mechanisms u
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Record Fields
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- Reference Id
- 2477
- Evidence Id
- 19067
- Core Evidence Id
- 19067
- Source Reference Id
- 4980
- Herb2 Reference Id
- HBREF005777
- Subject Paper Key
- HBIN036721_36123318
- Pubmed Id
- 36123318
- Doi
- 10.1002/ptr.7609
- Paper Title
- Anti-Postmenopausal osteoporosis effects of Isopsoralen: A bioinformatics-integrated experimental study
- Paper Abstract
- Isopsoralen (IPRN), which comes from the fruit of Psoralea corylifolia, has been identified as a kind of phytoestrogen and has been proven to be effective for the treatment of osteoporosis (OP). However, the mechanisms underlying IPRN's anti-OP effects, especially the anti-postmenopausal osteoporosis (PMOP) effects, remain indistinct. Thus, this study aimed to investigate the effects and mechanisms of IPRN's anti-PMOP activity. In this study, the bioinformatics results predicted that IPRN could resist PMOP by targeting EGFR, AKT1, SRC, CCND1, ESR1 (ER-α), AR, PGR, BRCA1, PTGS2, and IGF1R. An ovariectomized (OVX) mice model and a H 2 O 2 -induced bone marrow mesenchyml stem cells (BMSCs) model confirmed that IPRN could inhibit the bone loss induced by OVX in mice and promote the osteogenic differentiation in H 2 O 2 -induced BMSCs by inhibiting oxidative stress and apoptosis. Moreover, IPRN could significantly produce the above effects by upregulating ESR1. IPRN might be a therapeutic agent for PMOP by acting as an estrogen replacement agent and a natural antioxidant.
- Journal
- Phytother Res
- Publish Year
- 2022
- Experiment Subject
- mouse; bone marrow mesenchyml stem cells
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Osteoporosis; Anti-postmenopausal Osteoporosis
- Paper Title Cn
- Paper Title En
- Anti-Postmenopausal osteoporosis effects of Isopsoralen: A bioinformatics-integrated experimental study
- Bilingual Status
- semi_complete