ReferenceID 2402
Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia
Neurobiol Aging
In Alzheimer's disease (AD), hyper-phosphorylation and aggregation of tau correlate with clinical progression and represent a valid therapeutic target. A recent 20-year prospective study revealed an association between m
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 2402
- Evidence Id
- 18992
- Core Evidence Id
- 18992
- Source Reference Id
- 4828
- Herb2 Reference Id
- HBREF005625
- Subject Paper Key
- HBIN034745_35334439
- Pubmed Id
- 35334439
- Doi
- 10.1016/j.neurobiolaging.2022.02.011
- Paper Title
- Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia
- Paper Abstract
- In Alzheimer's disease (AD), hyper-phosphorylation and aggregation of tau correlate with clinical progression and represent a valid therapeutic target. A recent 20-year prospective study revealed an association between moderate to high frequency of Finnish sauna bathing and a lower incidence of dementia and AD, but the molecular mechanisms underlying these benefits remain uncertain. Here, we tested the hypothesis that sauna-like conditions could lower tau phosphorylation by increasing body temperature. We observed a decrease in tau phosphorylation in wild-type and hTau mice as well as in neuron-like cells when exposed to higher temperatures. These effects were correlated with specific changes in phosphatase and kinase activities, but not with inflammatory or heat shock responses. We also used a drug strategy to promote thermogenesis: topical application of menthol, which led to a sustained increase in body temperature in hTau mice, concomitant with a significant decrease in tau phosphorylation. Our results suggest that sauna-like conditions or menthol treatment could lower tau pathology through mild hyperthermia, and may provide promising therapeutic strategies for AD and other tauopathies.
- Journal
- Neurobiol Aging
- Publish Year
- 2022
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Dementia; Hyperthermia; Alzheimer's Disease; Tauopathies
- Paper Title Cn
- Paper Title En
- Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia
- Bilingual Status
- semi_complete