ReferenceID 2268
Anti-nociceptive effects of magnolol via inhibition of TRPV1/P2Y and TLR4/NF-κB signaling in a postoperative pain model
Life Sci
Aims: The current study explored the anti-nociceptive activity of magnolol in post-incisional inflammatory nociceptive pain. Main methods: Preliminary, the anti-inflammatory, antioxidant, and cytoprotective potential of
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- Reference Id
- 2268
- Evidence Id
- 18858
- Core Evidence Id
- 18858
- Source Reference Id
- 4569
- Herb2 Reference Id
- HBREF005366
- Subject Paper Key
- HBIN034250_36414090
- Pubmed Id
- 36414090
- Doi
- 10.1016/j.lfs.2022.121202
- Paper Title
- Anti-nociceptive effects of magnolol via inhibition of TRPV1/P2Y and TLR4/NF-κB signaling in a postoperative pain model
- Paper Abstract
- Aims: The current study explored the anti-nociceptive activity of magnolol in post-incisional inflammatory nociceptive pain. Main methods: Preliminary, the anti-inflammatory, antioxidant, and cytoprotective potential of magnolol were confirmed against hydrogen peroxide (H 2 O 2 )-induced PC12 cells. Next, an in-vivo model of planter incision surgery was established in BALB/c mice. Tramadol 50 mg/kg intraperitoneal (i.p.) and magnolol (0.1, 1, 10 mg/kg i.p. + 10 mg/kg intra planter) were administered after plantar incision surgery and behavior parameters were measured. Key findings: The results indicate that magnolol significantly suppressed post-incision-induced mechanical allodynia, thermal hyperalgesia, and paw edema. Magnolol promisingly inhibited post-incision induces nitric oxide (NO), malondialdehyde (MDA), eosinophil peroxidase (EPO), and neutrophil infiltration. Magnolol strongly attenuated post-incision inducing the release of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and inhibited deoxyribonucleic acid (DNA) fragmentation. Magnolol markedly reverses post-incisional histopathological changes and biochemical composition of the incised paw. Magnolol markedly down-regulated post-incisional increase expression of transient receptor potential vanilloid 1 (TRPV1), purinergic (P2Y) nociceptors as well as toll-like receptor 4 (TLR4), nuclear factor kappa light chain enhancer of activated B cell (NF-κB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) while upregulating the expression of inhibitor of nuclear kappa B alpha (IκB-α). Significance: The present study strongly suggests that magnolol significantly suppressed post-incisional inflammatory nociceptive pain by targeting TRPV1/P2Y and TLR4/NF-κB signaling.
- Journal
- Life Sci
- Publish Year
- 2022
- Experiment Subject
- mouse; pc12 cells
- Experiment Type
- Animal Experiment
- Phenotype Related
- Post-incisional Inflammatory Nociceptive Pain; Thermal Hyperalgesia; Tumor; Paw Edema
- Paper Title Cn
- Paper Title En
- Anti-nociceptive effects of magnolol via inhibition of TRPV1/P2Y and TLR4/NF-κB signaling in a postoperative pain model
- Bilingual Status
- semi_complete