ReferenceID 2240
Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE-/- mice
Eur J Nutr
PURPOSE: Nonalcoholic fatty liver disease (NAFLD) is currently the leading cause of chronic liver disease in developing countries. The pathogenesis is complex, and there is currently no effective treatment. Betaine is an
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Record Fields
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- Reference Id
- 2240
- Evidence Id
- 18830
- Core Evidence Id
- 18830
- Source Reference Id
- 4519
- Herb2 Reference Id
- HBREF005316
- Subject Paper Key
- HBIN033911_32808060
- Pubmed Id
- 32808060
- Doi
- 10.1007/s00394-020-02362-6
- Paper Title
- Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE-/- mice
- Paper Abstract
- PURPOSE: Nonalcoholic fatty liver disease (NAFLD) is currently the leading cause of chronic liver disease in developing countries. The pathogenesis is complex, and there is currently no effective treatment. Betaine is an essential intermediate in choline catabolism and an important component of the methionine cycle. Betaine deficiency is associated with NAFLD severity, and its mechanism needs to be further elaborated. METHODS: In this study, an NAFLD mouse model was established by feeding ApoE-/- mice a high-fat diet. The effects of betaine on NAFLD were investigated, including its mechanism. RESULTS: In this study, after treatment with betaine, blood lipid levels and liver damage were significantly decreased in the NAFLD mouse model. The fat infiltration of the liver tissues of high-fat diet (HFD)-fed mice after betaine administration was significantly improved. Betaine treatment significantly upregulated AMP-activated protein kinase (AMPK), fibroblast growth factor 10 (FGF10), and adipose triglyceride lipase (ATGL) protein levels both in vivo and in vitro and suppressed lipid metabolism-related genes. Furthermore, the overexpression of FGF10 increased the protein level of AMPK and decreased lipid accumulation in HepG2 cells. CONCLUSION: Taken together, the data strongly suggest that betaine significantly prevents high-fat diet-induced NAFLD through the FGF10/AMPK signaling pathway in ApoE-/- mice.
- Journal
- Eur J Nutr
- Publish Year
- 2021
- Experiment Subject
- mouse; hepg2 cells
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Nonalcoholic Fatty Liver Disease; Betaine Deficiency; Chronic Liver Disease
- Paper Title Cn
- Paper Title En
- Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE-/- mice
- Bilingual Status
- semi_complete