ReferenceID 2205
Osteoprotective Effects of Loganic Acid on Osteoblastic and Osteoclastic Cells and Osteoporosis-Induced Mice
Int J Mol Sci
Osteoporosis is a common disease caused by an imbalance of processes between bone resorption by osteoclasts and bone formation by osteoblasts in postmenopausal women. The roots of Gentiana lutea L. (GL) are reported to h
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Record Fields
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- Reference Id
- 2205
- Evidence Id
- 18795
- Core Evidence Id
- 18795
- Source Reference Id
- 4452
- Herb2 Reference Id
- HBREF005249
- Subject Paper Key
- HBIN033472_33379387
- Pubmed Id
- 33379387
- Doi
- 10.3390/ijms22010233
- Paper Title
- Osteoprotective Effects of Loganic Acid on Osteoblastic and Osteoclastic Cells and Osteoporosis-Induced Mice
- Paper Abstract
- Osteoporosis is a common disease caused by an imbalance of processes between bone resorption by osteoclasts and bone formation by osteoblasts in postmenopausal women. The roots of Gentiana lutea L. (GL) are reported to have beneficial effects on various human diseases related to liver functions and gastrointestinal motility, as well as on arthritis. Here, we fractionated and isolated bioactive constituent(s) responsible for anti-osteoporotic effects of GL root extract. A single phytochemical compound, loganic acid, was identified as a candidate osteoprotective agent. Its anti-osteoporotic effects were examined in vitro and in vivo. Treatment with loganic acid significantly increased osteoblastic differentiation in preosteoblast MC3T3-E1 cells by promoting alkaline phosphatase activity and increasing mRNA expression levels of bone metabolic markers such as Alpl, Bglap, and Sp7. However, loganic acid inhibited osteoclast differentiation of primary-cultured monocytes derived from mouse bone marrow. For in vivo experiments, the effect of loganic acid on ovariectomized (OVX) mice was examined for 12 weeks. Loganic acid prevented OVX-induced bone mineral density loss and improved bone structural properties in osteoporotic model mice. These results suggest that loganic acid may be a potential therapeutic candidate for treatment of osteoporosis.
- Journal
- Int J Mol Sci
- Publish Year
- 2020
- Experiment Subject
- mouse; human; preosteoblast mc3t3-e1 cells; primary-cultured monocytes; women
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Osteoporotic; Osteoporosis; Arthritis
- Paper Title Cn
- Paper Title En
- Osteoprotective Effects of Loganic Acid on Osteoblastic and Osteoclastic Cells and Osteoporosis-Induced Mice
- Bilingual Status
- semi_complete