ReferenceID 2195
Antimicrobial Activity and Proposed Action Mechanism of Linalool Against Pseudomonas fluorescens
Front Microbiol
In this study, linalool, one of the principal components of essential oils, was used as an antibacterial agent to investigate the antibacterial activity and mechanism of linalool against Pseudomonas fluorescens. The redu
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 2195
- Evidence Id
- 18785
- Core Evidence Id
- 18785
- Source Reference Id
- 4434
- Herb2 Reference Id
- HBREF005231
- Subject Paper Key
- HBIN033265_33584604
- Pubmed Id
- 33584604
- Doi
- 10.3389/fmicb.2021.562094
- Paper Title
- Antimicrobial Activity and Proposed Action Mechanism of Linalool Against Pseudomonas fluorescens
- Paper Abstract
- In this study, linalool, one of the principal components of essential oils, was used as an antibacterial agent to investigate the antibacterial activity and mechanism of linalool against Pseudomonas fluorescens. The reduction in membrane potential (MP), leakage of alkaline phosphatase (AKP) and the release of macromolecules, including DNA, RNA and protein confirmed that damage to cell wall membrane structure and leakage of cytoplasmic contents were due to the linalool treatment. Furthermore, the decrease of enzyme activity, including the succinate dehydrogenase (SDH), malate dehydrogenase (MDH), pyruvate kinase (PK), and ATPase indicated that linalool could lead to metabolic dysfunction and inhibit energy synthesis. In addition, the activity of respiratory chain dehydrogenase and metabolic activity of respiration indicated that linalool inhibits cellular respiration. These results revealed that linalool had strong antibacterial activity against P. fluorescens via membrane damage, bacterial metabolic and oxidative respiratory perturbations, interfering in cellular functions and even causing cell death. It was suggested that linalool may be a new potential source as food antiseptics in food systems.
- Journal
- Front Microbiol
- Publish Year
- 2021
- Experiment Subject
- Experiment Type
- Cell Experiment
- Phenotype Related
- Metabolic Dysfunction
- Paper Title Cn
- Paper Title En
- Antimicrobial Activity and Proposed Action Mechanism of Linalool Against Pseudomonas fluorescens
- Bilingual Status
- semi_complete