ReferenceID 2186
Ligustilide Attenuates Ischemia Reperfusion-Induced Hippocampal Neuronal Apoptosis via Activating the PI3K/Akt Pathway
Front Pharmacol
Ligustilide (LIG), a main lipophilic component isolated from Cnidii Rhizoma (Cnidium officinale, rhizome) and Angelicae Gigantis Radix (Angelica gigas Nakai, root), has been shown to alleviate cerebral ischemia injury an
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Record Fields
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- Reference Id
- 2186
- Evidence Id
- 18776
- Core Evidence Id
- 18776
- Source Reference Id
- 4418
- Herb2 Reference Id
- HBREF005215
- Subject Paper Key
- HBIN033198_32676033
- Pubmed Id
- 32676033
- Doi
- 10.3389/fphar.2020.00979
- Paper Title
- Ligustilide Attenuates Ischemia Reperfusion-Induced Hippocampal Neuronal Apoptosis via Activating the PI3K/Akt Pathway
- Paper Abstract
- Ligustilide (LIG), a main lipophilic component isolated from Cnidii Rhizoma (Cnidium officinale, rhizome) and Angelicae Gigantis Radix (Angelica gigas Nakai, root), has been shown to alleviate cerebral ischemia injury and paly a neuroprotective role. We investigated mechanisms underlying the antiapoptotic effects of LIG in vitro and in vivo, respectively, using cultured primary hippocampal neurons under oxygen-glucose deprivation/reperfusion (OGD/R) and rats under cerebral ischemia reperfusion(I/R) conditions. In vitro studies revealed that the suppressed apoptosis in hippocampal neurons upon LIG treatment was associated with reduced calcium influx and generation of reactive oxygen species. The LIG-treated hippocampal neurons exhibited decreased the ratio of Bax/Bcl-2, and the release of CytC from mitochondria as well as the expression of cleaved caspase-3, which were accompanied with enhanced the phosphorylation of Akt protein, in a PI3K-dependent manner. In vivo studies demonstrated a neuroprotective role of LIG in attenuating cerebral infarction volume, neurological injury and hippocampal neuron injury, suggesting that LIG could reverse ischemia reperfusion(I/R)-induced apoptosis of hippocampal neurons. These results together suggest that LIG may be considered as a neuroprotectant in the treatment of ischemia stroke.
- Journal
- Front Pharmacol
- Publish Year
- 2020
- Experiment Subject
- rat; cultured primary hippocampal neurons; lig-treated hippocampal neurons
- Experiment Type
- Animal Experiment
- Phenotype Related
- Hippocampal Neuron Injury; Neurological Injury; Cerebral Ischemia Injury; Cerebral Infarction; Ischemia Stroke
- Paper Title Cn
- Paper Title En
- Ligustilide Attenuates Ischemia Reperfusion-Induced Hippocampal Neuronal Apoptosis via Activating the PI3K/Akt Pathway
- Bilingual Status
- semi_complete