ReferenceID 2177
miR-195-3p alleviates homocysteine-mediated atherosclerosis by targeting IL-31 through its epigenetics modifications
Aging Cell
Atherosclerosis is a serious age-related disease, which has a tremendous impact on health care globally. Macrophage inflammation is crucial for the initiation and progression of atherosclerosis, and microRNAs (miRNAs) re
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Record Fields
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- Reference Id
- 2177
- Evidence Id
- 18767
- Core Evidence Id
- 18767
- Source Reference Id
- 4405
- Herb2 Reference Id
- HBREF005202
- Subject Paper Key
- HBIN033053_34592792
- Pubmed Id
- 34592792
- Doi
- 10.1111/acel.13485
- Paper Title
- miR-195-3p alleviates homocysteine-mediated atherosclerosis by targeting IL-31 through its epigenetics modifications
- Paper Abstract
- Atherosclerosis is a serious age-related disease, which has a tremendous impact on health care globally. Macrophage inflammation is crucial for the initiation and progression of atherosclerosis, and microRNAs (miRNAs) recently have emerged as potent modulators of inflammation, while the underlying mechanisms of its involvement in homocysteine (Hcy)-mediated macrophage inflammation of atherosclerosis remain largely unknown. Here, we demonstrated that elevated Hcy inhibits the expression of miR-195-3p, which in turn enhances IL-31 expression and thereby causes the secretion of macrophages pro-inflammatory factors IL-1beta, IL-6 and TNF-alpha and accelerate atherosclerosis. Furthermore, we identified that Hcy can induce DNA hypermethylation and H3K9 deacetylation of miR-195-3p promoter due to the increased the binding of DNMT3a and HDAC11 at its promoter. More importantly, Sp1 interacts with DNMT3a suppressed the binding of HDAC11 at miR-195-3p promoter and promoted its transcription. In summary, our results revealed a novel mechanism that transcriptional and epigenetic regulation of miR-195-3p inhibits macrophage inflammation through targeting IL-31, which provides a candidate diagnostic marker and novel therapeutic target in cardiovascular diseases induced by Hcy.
- Journal
- Aging Cell
- Publish Year
- 2021
- Experiment Subject
- Experiment Type
- Animal Experiment
- Phenotype Related
- Atherosclerosis; Age-related Disease; Cardiovascular Diseases
- Paper Title Cn
- Paper Title En
- miR-195-3p alleviates homocysteine-mediated atherosclerosis by targeting IL-31 through its epigenetics modifications
- Bilingual Status
- semi_complete