ReferenceID 2152
The Cyr61 Is a Potential Target for Rotundifuran, a Natural Labdane-Type Diterpene from Vitex trifolia L., to Trigger Apoptosis of Cervical Cancer Cells
Oxid Med Cell Longev
Cervical cancer is a common female malignant tumor that seriously threatens human health. This study explored the anticervical cancer effects and potential mechanisms of Rotundifuran (RTF), a natural product isolated fro
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 2152
- Evidence Id
- 18742
- Core Evidence Id
- 18742
- Source Reference Id
- 5583
- Herb2 Reference Id
- HBREF006380
- Subject Paper Key
- HBIN042484_34234887
- Pubmed Id
- 34234887
- Doi
- 10.1155/2021/6677687
- Paper Title
- The Cyr61 Is a Potential Target for Rotundifuran, a Natural Labdane-Type Diterpene from Vitex trifolia L., to Trigger Apoptosis of Cervical Cancer Cells
- Paper Abstract
- Cervical cancer is a common female malignant tumor that seriously threatens human health. This study explored the anticervical cancer effects and potential mechanisms of Rotundifuran (RTF), a natural product isolated from Vitex trifolia L. In this study, we found that RTF can suppress the proliferation of cervical cancer cell lines, including HeLa and SiHa cells (with the IC50 less than 10 muM), via induction of apoptosis in vitro, and the antitumor effect of RTF is further confirmed on the HeLa cell-inoculated xenograft model. In addition, our results proved that the antitumor effects of RTF might be related with the reactive oxygen species- (ROS-) induced mitochondrial-dependent apoptosis through MAPK and PI3K/Akt signal pathways. Using proteomics analysis and the drug affinity responsive target stability- (DARTS-) combined mass spectrometry (DARTS-MS), Cyr61 was indicated as a potential target for RTF in cervical cancer cells. Our present study would be beneficial for the development of RTF as a candidate for treatment of cervical cancer in the future.
- Journal
- Oxid Med Cell Longev
- Publish Year
- 2021
- Experiment Subject
- human; cervical cancer cell lines; hela; siha cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Malignant Tumor; Anticervical Cancer; Cervical Cancer
- Paper Title Cn
- Paper Title En
- The Cyr61 Is a Potential Target for Rotundifuran, a Natural Labdane-Type Diterpene from Vitex trifolia L., to Trigger Apoptosis of Cervical Cancer Cells
- Bilingual Status
- semi_complete