ReferenceID 2141
Kurarinone Attenuates BLM-Induced Pulmonary Fibrosis via Inhibiting TGF-β Signaling Pathways
Int J Mol Sci
Idiopathic pulmonary fibrosis (IPF) is a refractory interstitial lung disease for which there is no effective treatment. Although the pathogenesis of IPF is not fully understood, TGF-beta and epithelial-mesenchymal trans
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- Reference Id
- 2141
- Evidence Id
- 18731
- Core Evidence Id
- 18731
- Source Reference Id
- 4324
- Herb2 Reference Id
- HBREF005121
- Subject Paper Key
- HBIN032371_34445094
- Pubmed Id
- 34445094
- Doi
- 10.3390/ijms22168388
- Paper Title
- Kurarinone Attenuates BLM-Induced Pulmonary Fibrosis via Inhibiting TGF-β Signaling Pathways
- Paper Abstract
- Idiopathic pulmonary fibrosis (IPF) is a refractory interstitial lung disease for which there is no effective treatment. Although the pathogenesis of IPF is not fully understood, TGF-beta and epithelial-mesenchymal transition (EMT) have been shown to be involved in the fibrotic changes of lung tissues. Kurarinone is a prenylated flavonoid isolated from Sophora Flavescens with antioxidant and anti-inflammatory properties. In this study, we investigated the effect of kurarinone on pulmonary fibrosis. Kurarinone suppressed the TGF-beta-induced EMT of lung epithelial cells. To assess the therapeutic effects of kurarinone in bleomycin (BLM)-induced pulmonary fibrosis, mice were treated with kurarinone daily for 2 weeks starting 7 days after BLM instillation. Oral administration of kurarinone attenuated the fibrotic changes of lung tissues, including accumulation of collagen and improved mechanical pulmonary functions. Mechanistically, kurarinone suppressed phosphorylation of Smad2/3 and AKT induced by TGF-beta1 in lung epithelial cells, as well as in lung tissues treated with BLM. Taken together, these results suggest that kurarinone has a therapeutic effect on pulmonary fibrosis via suppressing TGF-beta signaling pathways and may be a novel drug candidate for pulmonary fibrosis.
- Journal
- Int J Mol Sci
- Publish Year
- 2021
- Experiment Subject
- mouse
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Idiopathic Pulmonary Fibrosis; Interstitial Lung Disease; Pulmonary Fibrosis
- Paper Title Cn
- Paper Title En
- Kurarinone Attenuates BLM-Induced Pulmonary Fibrosis via Inhibiting TGF-β Signaling Pathways
- Bilingual Status
- semi_complete