ReferenceID 2131
Seomae mugwort and jaceosidin attenuate osteoarthritic cartilage damage by blocking IκB degradation in mice
J Cell Mol Med
Seomae mugwort, a Korean native variety of Artemisia argyi, exhibits physiological effects against various diseases. However, its effects on osteoarthritis (OA) are unclear. In this study, a Seomae mugwort extract preven
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Record Fields
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- Reference Id
- 2131
- Evidence Id
- 18721
- Core Evidence Id
- 18721
- Source Reference Id
- 4297
- Herb2 Reference Id
- HBREF005094
- Subject Paper Key
- HBIN031409_32529755
- Pubmed Id
- 32529755
- Doi
- 10.1111/jcmm.15471
- Paper Title
- Seomae mugwort and jaceosidin attenuate osteoarthritic cartilage damage by blocking IκB degradation in mice
- Paper Abstract
- Seomae mugwort, a Korean native variety of Artemisia argyi, exhibits physiological effects against various diseases. However, its effects on osteoarthritis (OA) are unclear. In this study, a Seomae mugwort extract prevented cartilage destruction in an OA mouse model. In vitro and ex vivo analyses revealed that the extract suppressed MMP3, MMP13, ADAMTS4 and ADAMTS5 expression induced by IL-1beta, IL-6 and TNF-alpha and inhibited the loss of extracellular sulphated proteoglycans. In vivo analysis revealed that oral administration of the extract suppressed DMM-induced cartilage destruction. We identified jaceosidin in Seomae mugwort and showed that this compound decreased MMP3, MMP13, ADAMTS4 and ADAMTS5 expression levels, similar to the action of the Seomae mugwort extract in cultured chondrocytes. Interestingly, jaceosidin and eupatilin combined had similar effects to Seomae mugwort in the DMM-induced OA model. Induction of IkappaB degradation by IL-1beta was blocked by the extract and jaceosidin, whereas JNK phosphorylation was only suppressed by the extract. These results suggest that the Seomae mugwort extract and jaceosidin can attenuate cartilage destruction by suppressing MMPs, ADAMTS4/5 and the nuclear factor-kappaB signalling pathway by blocking IkappaB degradation. Thus, the findings support the potential application of Seomae mugwort, and particularly jaceosidin, as natural therapeutics for OA.
- Journal
- J Cell Mol Med
- Publish Year
- 2020
- Experiment Subject
- mouse; cultured chondrocytes
- Experiment Type
- Animal Experiment
- Phenotype Related
- Osteoarthritis
- Paper Title Cn
- Paper Title En
- Seomae mugwort and jaceosidin attenuate osteoarthritic cartilage damage by blocking IκB degradation in mice
- Bilingual Status
- semi_complete