ReferenceID 2109
Isatin inhibits the invasion and metastasis of SH‑SY5Y neuroblastoma cells in vitro and in vivo
Int J Oncol
Indoline-2,3-dione or indole-1H-2,3-dione, commonly known as isatin, is found in plants of genus Isatin and in Couropita guianancis aubl, and inhibits tumor cell proliferation through its antioxidant effects. The present
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 2109
- Evidence Id
- 18699
- Core Evidence Id
- 18699
- Source Reference Id
- 4243
- Herb2 Reference Id
- HBREF005040
- Subject Paper Key
- HBIN030370_33367935
- Pubmed Id
- 33367935
- Doi
- 10.3892/ijo.2020.5144
- Paper Title
- Isatin inhibits the invasion and metastasis of SH‑SY5Y neuroblastoma cells in vitro and in vivo
- Paper Abstract
- Indoline-2,3-dione or indole-1H-2,3-dione, commonly known as isatin, is found in plants of genus Isatin and in Couropita guianancis aubl, and inhibits tumor cell proliferation through its antioxidant effects. The present study analyzed the effect of isatin on the malignant phenotype of neuroblastoma cells, and reported that isatin significantly inhibited neuroblastoma cell proliferation, invasion and migration in vitro in a dose-dependent manner, and distant metastasis in tumor-bearing mice. Mechanistically, isatin inhibited lysine-specific histone demethylase (LSD)1 and reversed the blockade on p53, thereby activating the apoptotic pathway. The inhibitory effect of isatin on LSD1 may be mediated via direct binding and molecular docking or indirectly through the TGFbeta/ERK/NF-kappaB signaling pathway. Isatin also alleviated the renal and hepatic toxicity of cyclophosphamide in the tumor-bearing mice, indicating its potential as a candidate drug as well as an adjuvant for treating metastatic neuroblastoma.
- Journal
- Int J Oncol
- Publish Year
- 2021
- Experiment Subject
- mouse; neuroblastoma cell
- Experiment Type
- Animal Experiment
- Phenotype Related
- Metastatic Neuroblastoma; Tumor; Neuroblastoma
- Paper Title Cn
- Paper Title En
- Isatin inhibits the invasion and metastasis of SH‑SY5Y neuroblastoma cells in vitro and in vivo
- Bilingual Status
- semi_complete