ReferenceID 197
Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines
Cancer Lett
In this study, we investigated the anticancer effect of protopine on human hormone-refractory prostate cancer (HRPC) cells. Protopine exhibited an anti-proliferative effect by induction of tubulin polymerization and mito
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 197
- Evidence Id
- 16787
- Core Evidence Id
- 16787
- Source Reference Id
- 357
- Herb2 Reference Id
- HBREF000648
- Subject Paper Key
- HBIN040936_22033245
- Pubmed Id
- 22033245
- Doi
- 10.1016/j.canlet.2011.09.042
- Paper Title
- Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines
- Paper Abstract
- In this study, we investigated the anticancer effect of protopine on human hormone-refractory prostate cancer (HRPC) cells. Protopine exhibited an anti-proliferative effect by induction of tubulin polymerization and mitotic arrest, which ultimately led to apoptotic cell death. The data suggest that protopine increased the activity of cyclin-dependent kinase 1 (Cdk1)/cyclin B1 complex and that contributed to cell apoptosis by modulating mitochondria-mediated signaling pathways, such as Bcl-2 phosphorylation and Mcl-1 down-regulation. In conclusion, the data suggest that protopine is a novel microtubule stabilizer with anticancer activity in HRPC cells through apoptotic pathway by modulating Cdk1 activity and Bcl-2 family of proteins.
- Journal
- Cancer Lett
- Publish Year
- 2012
- Experiment Subject
- human hormone-refractory prostate cancer cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines
- Bilingual Status
- semi_complete