ReferenceID 1925
Genipin Attenuates Tau Phosphorylation and Aβ Levels in Cellular Models of Alzheimer's Disease
Mol Neurobiol
Alzheimer's disease (AD) is a devastating brain disorder characterized by neurofibrillary tangles and amyloid plaques. Inhibiting Tau protein and amyloid-beta (Abeta) production or removing these molecules is considered
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Record Fields
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- Reference Id
- 1925
- Evidence Id
- 18515
- Core Evidence Id
- 18515
- Source Reference Id
- 3859
- Herb2 Reference Id
- HBREF004656
- Subject Paper Key
- HBIN027445_33948899
- Pubmed Id
- 33948899
- Doi
- 10.1007/s12035-021-02389-8
- Paper Title
- Genipin Attenuates Tau Phosphorylation and Aβ Levels in Cellular Models of Alzheimer's Disease
- Paper Abstract
- Alzheimer's disease (AD) is a devastating brain disorder characterized by neurofibrillary tangles and amyloid plaques. Inhibiting Tau protein and amyloid-beta (Abeta) production or removing these molecules is considered potential therapeutic strategies for AD. Genipin is an aglycone and is isolated from the extract of Gardenia jasminoides Ellis fruit. In this study, the effect and molecular mechanisms of genipin on the inhibition of Tau aggregation and Abeta generation were investigated. The results showed that genipin bound to Tau and protected against heparin-induced Tau fibril formation. Moreover, genipin suppressed Tau phosphorylation probably by downregulating the expression of CDK5 and GSK-3beta, and activated mTOR-dependent autophagy via the SIRT1/LKB1/AMPK signaling pathway in Tau-overexpressing cells. In addition, genipin decreased Abeta production by inhibiting BACE1 expression through the PERK/eIF2alpha signaling pathway in N2a/SweAPP cells. These data indicated that genipin could effectively lead to a significant reduction of phosphorylated Tau level and Abeta generation in vitro, suggesting that genipin might be developed into an effective therapeutic complement or a potential nutraceutical for preventing AD.
- Journal
- Mol Neurobiol
- Publish Year
- 2021
- Experiment Subject
- fruit; n2a/sweapp cells; tau-overexpressing cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Devastating Brain Disorder; Alzheimer's Disease; Neurofibrillary Tangles And Amyloid Plaques
- Paper Title Cn
- Paper Title En
- Genipin Attenuates Tau Phosphorylation and Aβ Levels in Cellular Models of Alzheimer's Disease
- Bilingual Status
- semi_complete