ReferenceID 1898
Galangin ameliorates osteoarthritis progression by attenuating extracellular matrix degradation in chondrocytes via the activation of PRELP expression
Eur J Pharmacol
Osteoarthritis (OA) is primarily characterized by progressive degeneration and destruction of articular cartilage. Currently, there is no effective method to treat OA. The metabolic disturbance of cartilage extracellular
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Record Fields
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- Reference Id
- 1898
- Evidence Id
- 18488
- Core Evidence Id
- 18488
- Source Reference Id
- 3828
- Herb2 Reference Id
- HBREF004625
- Subject Paper Key
- HBIN027003_36367487
- Pubmed Id
- 36367487
- Doi
- 10.1016/j.ejphar.2022.175347
- Paper Title
- Galangin ameliorates osteoarthritis progression by attenuating extracellular matrix degradation in chondrocytes via the activation of PRELP expression
- Paper Abstract
- Osteoarthritis (OA) is primarily characterized by progressive degeneration and destruction of articular cartilage. Currently, there is no effective method to treat OA. The metabolic disturbance of cartilage extracellular matrix (ECM) and oxidative stress are critical to promote OA progression. Galangin (Gal) is a small molecule compound that pertains to flavonoids. To determine the protective effect and mechanism of Gal against OA progression, various experiments were performed in vitro and in vivo. In vitro, Gal promoted ECM production and attenuated ECM degradation in human OA chondrocytes. The expression of ECM components from human OA cartilage explants was also stimulated by Gal treatment. As demonstrated from the in vivo study, the intra-articular injection of Gal delayed OA progression in rat models. Moreover, RNA sequencing analysis showed that proline/arginine-rich end leucine repeat protein (PRELP) was a molecular target of Gal activity. Gal inhibited oxidative stress and attenuated ECM degradation by activating PRELP expression. The study demonstrated that Gal could attenuate ECM degradation and ameliorate OA progression, and PRELP may be a potential candidate drug of Gal for treating OA.
- Journal
- Eur J Pharmacol
- Publish Year
- 2022
- Experiment Subject
- rat; human
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Osteoarthritis; Degeneration And Destruction Of Articular Cartilage
- Paper Title Cn
- Paper Title En
- Galangin ameliorates osteoarthritis progression by attenuating extracellular matrix degradation in chondrocytes via the activation of PRELP expression
- Bilingual Status
- semi_complete