ReferenceID 1895
Preventive effects of fraxin on ischemia/reperfusion-induced acute kidney injury in rats
Life Sci
AIM: Kidney ischemia reperfusion (IR) injury is an important health problem resulting in acute kidney failure. The oxidative stress and inflammatory process are the underlying mechanisms of IR injury. It has been purpose
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Record Fields
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- Reference Id
- 1895
- Evidence Id
- 18485
- Core Evidence Id
- 18485
- Source Reference Id
- 3798
- Herb2 Reference Id
- HBREF004595
- Subject Paper Key
- HBIN026737_31884094
- Pubmed Id
- 31884094
- Doi
- 10.1016/j.lfs.2019.117217
- Paper Title
- Preventive effects of fraxin on ischemia/reperfusion-induced acute kidney injury in rats
- Paper Abstract
- AIM: Kidney ischemia reperfusion (IR) injury is an important health problem resulting in acute kidney failure. The oxidative stress and inflammatory process are the underlying mechanisms of IR injury. It has been purposed in this study to research the possible protective effects of fraxin on kidney injury induced by IR. MATERIAL AND METHODS: 32 Sprague Dawley male rats were divided into 4 groups. The groups were organized as follows; sham, IR, IR + fraxin 10 mg/kg, and IR + 50 mg/kg fraxin groups. Some oxidant, antioxidant and inflammatory parameters were evaluated in kidney tissues removed at the end of our experimental study. KEY FINDINGS: It was detected that the oxidant and proinflammatory markers increased and antioxidant parameters decreased in IR group but the results significantly reversed in treatment groups compared to IR group. And also, 8-OHdG, NF-kappaB, HAVCR1 immunopositivities were at severe levels and these results attenuated in IR fraxin + 10 mg/kg, and IR + fraxin 50 mg/kg groups. SIGNIFICANCE: These presented results have shown that fraxin performed protective effects against kidney injury induced by IR.
- Journal
- Life Sci
- Publish Year
- 2020
- Experiment Subject
- rat
- Experiment Type
- Animal Experiment
- Phenotype Related
- Ir Injury; Kidney Ischemia Reperfusion; Ir) Injury; Acute Kidney Failure; Kidney Injury
- Paper Title Cn
- Paper Title En
- Preventive effects of fraxin on ischemia/reperfusion-induced acute kidney injury in rats
- Bilingual Status
- semi_complete