ReferenceID 1814
Ellipticine blocks synergistic effects of IL-17A and TNF-α in epithelial cells and alleviates severe acute pancreatitis-associated acute lung injury
Biochem Pharmacol
IL-17A combined with TNF-alpha plays a vital role in inflammatory response and interference of the synergistic effect is an effective strategy for treating inflammatory diseases. Ellipticine, a natural alkaloid, has biol
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- Reference Id
- 1814
- Evidence Id
- 18404
- Core Evidence Id
- 18404
- Source Reference Id
- 3614
- Herb2 Reference Id
- HBREF004411
- Subject Paper Key
- HBIN025012_32335141
- Pubmed Id
- 32335141
- Doi
- 10.1016/j.bcp.2020.113992
- Paper Title
- Ellipticine blocks synergistic effects of IL-17A and TNF-α in epithelial cells and alleviates severe acute pancreatitis-associated acute lung injury
- Paper Abstract
- IL-17A combined with TNF-alpha plays a vital role in inflammatory response and interference of the synergistic effect is an effective strategy for treating inflammatory diseases. Ellipticine, a natural alkaloid, has biological activities on anti-tumor and anti-HIV. However, it is still unknown whether ellipticine can inhibit IL-17A and TNF-alpha-mediated signaling and has treatment effect on PALI. Here, we reported that ellipticine significantly inhibited the production of pro-inflammatory cytokines and chemokines in pulmonary epithelial cell BEAS-2B treated with IL-17A and TNF-alpha, but not IL-17A or TNF-alpha alone. Meanwhile, ellipticine attenuated NF-kappaB and MAPKs activation in response to IL-17A and TNF-alpha treatment, inhibited Act1 and TRAF6-mediated NF-kappaB activation, and blocked the interaction of Act1 with TRAF6. Furthermore, we found that ellipticine significantly alleviated CAE and LPS-induced SAP/PALI. Ellipticine treatment dramatically reduced inflammatory cells infiltration, MPO activity, serum amylase and lipase activity and the protein concentration of BALF. Collectively, our findings indicate that ellipticine inhibits the synergistic effect of IL-17A and TNF-alpha by targeting on Act1 and TRAF6 interaction and is a potential therapeutic agent for the treatment of SAP/PALI.
- Journal
- Biochem Pharmacol
- Publish Year
- 2020
- Experiment Subject
- Experiment Type
- Cell Experiment
- Phenotype Related
- Inflammatory Diseases
- Paper Title Cn
- Paper Title En
- Ellipticine blocks synergistic effects of IL-17A and TNF-α in epithelial cells and alleviates severe acute pancreatitis-associated acute lung injury
- Bilingual Status
- semi_complete