ReferenceID 1801
Eckol from Ecklonia cava Suppresses Immunoglobulin E-mediated Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mice
Nutrients
Eckol, a precursor compound belonging to the dibenzo-1,4-dioxin class of phlorotannins, is a phloroglucinol derivative that exerts various activities. In the present study, we investigated the antiallergic effects of eck
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Record Fields
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- Reference Id
- 1801
- Evidence Id
- 18391
- Core Evidence Id
- 18391
- Source Reference Id
- 3587
- Herb2 Reference Id
- HBREF004384
- Subject Paper Key
- HBIN024823_32397556
- Pubmed Id
- 32397556
- Doi
- 10.3390/nu12051361
- Paper Title
- Eckol from Ecklonia cava Suppresses Immunoglobulin E-mediated Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mice
- Paper Abstract
- Eckol, a precursor compound belonging to the dibenzo-1,4-dioxin class of phlorotannins, is a phloroglucinol derivative that exerts various activities. In the present study, we investigated the antiallergic effects of eckol isolated from the marine brown algae, Ecklonia cava using immunoglobulin E (IgE)/bovine serum albumin (BSA)-stimulated mouse bone marrow-derived cultured mast cells (BMCMC) and a mouse model of anaphylaxis. Eckol inhibited IgE/BSA-induced BMCMC degranulation by reducing beta-hexosaminidase release. A flow cytometric analysis revealed that eckol decreases FcepsilonRI expression on cell surface and IgE binding to the FcepsilonRI in BMCMC. Moreover, eckol suppressed the production of the cytokines, interleukin (IL)-4, IL-5, IL-6, and IL-13 and the chemokine, thymus activation-regulated chemokine (TARC) by downregulating, IkappaB-alpha degradation and NF-kappaB nuclear translocation. Furthermore, it attenuated the passive cutaneous anaphylactic reaction induced by IgE/BSA-stimulation in the ear of BALB/c mice. These results suggest that eckol is a potential therapeutic candidate for the prevention and treatment of allergic disorders.
- Journal
- Nutrients
- Publish Year
- 2020
- Experiment Subject
- mouse; bovine; immunoglobulin e (ige)/bovine serum albumin (bsa)-stimulated mouse bone marrow-derived cultured mast cells
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Allergic Disorders; Anaphylaxis
- Paper Title Cn
- Paper Title En
- Eckol from Ecklonia cava Suppresses Immunoglobulin E-mediated Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mice
- Bilingual Status
- semi_complete