ReferenceID 1796
Echinacoside Protects Dopaminergic Neurons Through Regulating IL-6/JAK2/STAT3 Pathway in Parkinson's Disease Model
Front Pharmacol
Echinacoside (ECH), the major active constituent of Cistanche deserticola , was found to exert neuroprotection through neurotrophic and anti-inflammatory functions in Parkinson's disease (PD) models. However, a clear int
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 1796
- Evidence Id
- 18386
- Core Evidence Id
- 18386
- Source Reference Id
- 3580
- Herb2 Reference Id
- HBREF004377
- Subject Paper Key
- HBIN024794_35281889
- Pubmed Id
- 35281889
- Doi
- 10.3389/fphar.2022.848813
- Paper Title
- Echinacoside Protects Dopaminergic Neurons Through Regulating IL-6/JAK2/STAT3 Pathway in Parkinson's Disease Model
- Paper Abstract
- Echinacoside (ECH), the major active constituent of Cistanche deserticola , was found to exert neuroprotection through neurotrophic and anti-inflammatory functions in Parkinson's disease (PD) models. However, a clear intermediate molecule or pathway that unifies these two effects has to be found. In this study, our results demonstrate that ECH can protect DA neurons in PD mice with Western blot and immunohistochemistry staining. The quantitative real-time polymerase chain reaction was adapted to confirm its anti-inflammatory function with decreased cytokines (interleukin- (IL-) 6, IL-1β, and TNF-α) in PD mice and LPS-induced BV2 cells. Further studies found that ECH inhibited the IL-6/JAK2/STAT3 pathway and decreased phosphorylation of STAT3 on tyr705 by Western blot. It can also increase p-STAT3 (ser727) and brain-derived neurotrophic factor (BDNF) expression in PD mice and LPS-induced BV2 cells. This study revealed that ECH exerts neurotrophic and anti-inflammatory effects by regulating the IL-6/JAK2/STAT3 pathway and the phosphorylation of STAT3, promoting the mutually beneficial influence of the two effects to maximize its neuroprotective function.
- Journal
- Front Pharmacol
- Publish Year
- 2022
- Experiment Subject
- mouse; bv2 cells
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Parkinson's Disease
- Paper Title Cn
- Paper Title En
- Echinacoside Protects Dopaminergic Neurons Through Regulating IL-6/JAK2/STAT3 Pathway in Parkinson's Disease Model
- Bilingual Status
- semi_complete