ReferenceID 1793
Echinacoside improves diabetic liver injury by regulating the AMPK/SIRT1 signaling pathway in db/db mice
Life Sci
AIMS: Echinacoside (ECH) is a natural compound extracted from the stem of the Cistanche deserticola plant, has significant biological properties, including antioxidant, anti-inflammatory, neuroprotective, anti-tumor, hep
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- Reference Id
- 1793
- Evidence Id
- 18383
- Core Evidence Id
- 18383
- Source Reference Id
- 3577
- Herb2 Reference Id
- HBREF004374
- Subject Paper Key
- HBIN024794_33600859
- Pubmed Id
- 33600859
- Doi
- 10.1016/j.lfs.2021.119237
- Paper Title
- Echinacoside improves diabetic liver injury by regulating the AMPK/SIRT1 signaling pathway in db/db mice
- Paper Abstract
- AIMS: Echinacoside (ECH) is a natural compound extracted from the stem of the Cistanche deserticola plant, has significant biological properties, including antioxidant, anti-inflammatory, neuroprotective, anti-tumor, hepatoprotective, and immunomodulatory properties. In this study, we aimed to explore the protection effects and mechanisms of ECH on diabetic liver injury in db/db mice. MAIN METHODS: Overall, 6-week-old db/db mice (n = 20) were randomly allocated to 2 groups: diabetic model group (db/db group, intragastric administration of normal saline, n = 10) and ECH-treated group (db/db + ECH group, n = 10). Additionally, the normal control group comprised 6-week-old db/m mice (db/m group, normal saline intragastric administration, n = 10). ECH was administered once a day for 10 weeks. Weight and fasting blood glucose (FBG) were measured biweekly. HE staining and Oil O staining were used to evaluate liver tissue pathological changes and lipid accumulation respectively. Immunofluorescence staining, Western blot and RT-PCR analysis were used to detect the expression of components of the AMPK/SIRT1 signaling axis. KEY FINDINGS: The results showed that the administration of echinacoside for 10 weeks could significantly improve liver injury and insulin resistance in db/db mice (p < 0.01). Also, echinacoside treatment helped to reduce blood lipids and blood glucose (p < 0.01). Moreover, ECH actived AMPK/SIRT1 signaling, upregulated peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1alpha), proliferator-activated receptor-alpha (PPARalpha), carnitine palmitoyl transferase-1A (CPT1A) in db/db mice (p < 0.01). SIGNIFICANCE: The effect of ECH may be elicited by the activation of the liver AMPK/SIRT1 pathway and its downstream factors to improve adiposity, insulin resistance, and dyslipidemia.
- Journal
- Life Sci
- Publish Year
- 2021
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Diabetic Liver Injury; Dyslipidemia
- Paper Title Cn
- Paper Title En
- Echinacoside improves diabetic liver injury by regulating the AMPK/SIRT1 signaling pathway in db/db mice
- Bilingual Status
- semi_complete