ReferenceID 1788
Diosmin Mitigates Cyclophosphamide Induced Premature Ovarian Insufficiency in Rat Model
Int J Mol Sci
The current study was designed to investigate the protective role of diosmin against cyclophosphamide-induced premature ovarian insufficiency (POI). Female Swiss albino rats received a single intraperitoneal dose of cycl
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Record Fields
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- Reference Id
- 1788
- Evidence Id
- 18378
- Core Evidence Id
- 18378
- Source Reference Id
- 3566
- Herb2 Reference Id
- HBREF004363
- Subject Paper Key
- HBIN024193_33802633
- Pubmed Id
- 33802633
- Doi
- 10.3390/ijms22063044
- Paper Title
- Diosmin Mitigates Cyclophosphamide Induced Premature Ovarian Insufficiency in Rat Model
- Paper Abstract
- The current study was designed to investigate the protective role of diosmin against cyclophosphamide-induced premature ovarian insufficiency (POI). Female Swiss albino rats received a single intraperitoneal dose of cyclophosphamide (200 mg/kg) followed by 8 mg/kg/day for the next 15 consecutive days either alone or in combination with oral diosmin at 50 or 100 mg/kg. Histopathological examination of ovarian tissues, hormonal assays for follicle stimulating hormone (FSH), estradiol (E2), and anti-Mullerian hormone (AMH), assessment of the oxidative stress status, as well as measurement of the relative expression of miRNA-145 and its target genes [vascular endothelial growth factor B (VEGF-B) and regulator of cell cycle (RGC32)] were performed. Diosmin treatment ameliorated the levels of E2, AMH, and oxidative stress markers. Additionally, both low and high diosmin doses significantly reduced the histopathological alterations and nearly preserved the normal ovarian reserve. MiRNA-145 expression was upregulated after treatment with diosmin high dose. miRNA-145 target genes were over-expressed after both low and high diosmin administration. Based on our findings, diosmin has a dose-dependent protective effect against cyclophosphamide-induced ovarian toxicity in rats.
- Journal
- Int J Mol Sci
- Publish Year
- 2021
- Experiment Subject
- rat
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Cyclophosphamide-induced Premature Ovarian Insufficiency
- Paper Title Cn
- Paper Title En
- Diosmin Mitigates Cyclophosphamide Induced Premature Ovarian Insufficiency in Rat Model
- Bilingual Status
- semi_complete