ReferenceID 1707
Curdione Induces Antiproliferation Effect on Human Uterine Leiomyosarcoma via Targeting IDO1
Front Oncol
Objectives: Curdione is one of the active ingredients of a traditional Chinese herbal medicine-Curcuma zedoary and established anti-tumor effects. Uterine leiomyosarcoma (uLMS) is a rare gynecological malignancy, with no
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- Reference Id
- 1707
- Evidence Id
- 18297
- Core Evidence Id
- 18297
- Source Reference Id
- 3401
- Herb2 Reference Id
- HBREF004198
- Subject Paper Key
- HBIN021993_33718227
- Pubmed Id
- 33718227
- Doi
- 10.3389/fonc.2021.637024
- Paper Title
- Curdione Induces Antiproliferation Effect on Human Uterine Leiomyosarcoma via Targeting IDO1
- Paper Abstract
- Objectives: Curdione is one of the active ingredients of a traditional Chinese herbal medicine-Curcuma zedoary and established anti-tumor effects. Uterine leiomyosarcoma (uLMS) is a rare gynecological malignancy, with no standard therapeutic regimen at present. The aim of this study was to explore the potential anti-tumor impact of curdione in uLMS and elucidate the underlying mechanisms. Methods: In vitro functional assays were performed in the SK-UT-1 and SK-LMS-1 cell lines. The in vivo model of uLMS was established by subcutaneously injecting SK-UT-1 cells, and the tumor-bearing mice were intraperitoneally injected with curdione. Tumor weight and volume were measured at specific time points. The biosafety was evaluated by monitoring changes of body weight and the histopathology in the liver and kidney. The expression levels of relevant proteins were analyzed by western blotting and immunohistochemistry. Results: Curdione decreased the viability and proliferation of uLMS cells in a concentration and time-dependent manner. In addition, the curdione-treated cells exhibited significantly higher rates of apoptosis and autophagic death. Curdione also decreased the tumor weight and volume in the SK-UT-1 xenograft model compared to the untreated control without affecting the body bodyweight or pathological injury of liver and kidney tissues. At the molecular level, the anti-tumor effects of curdione were mediated by indoleamine-2, 3-dioxygenase-1 (IDO1). Conclusion: Curdione exhibited an anti-uLMS effect in vitro and in vivo; the underlying mechanism involved in IDO1 mediate apoptosis, autophagy, and G2/M phase arrest.
- Journal
- Front Oncol
- Publish Year
- 2021
- Experiment Subject
- mouse; curdione-treated cells; sk-lms-1 cell lines; sk-ut-1 cells; sk-ut-1 xenograft model; ulms; ulms cells
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Autophagic Death; Tumor; Uterine Leiomyosarcoma; Ulms; Gynecological Malignancy
- Paper Title Cn
- Paper Title En
- Curdione Induces Antiproliferation Effect on Human Uterine Leiomyosarcoma via Targeting IDO1
- Bilingual Status
- semi_complete