ReferenceID 1702
Curcumol inhibits EBV-positive Nasopharyngeal carcinoma migration and invasion by targeting nucleolin
Biochem Pharmacol
Metastasis is a major cause of recurrence and death in patients with EBV-positive Nasopharyngeal carcinoma (NPC). Previous reports documented that curcumol has both anti-cancer and anti-viral effects, but there is little
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Record Fields
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- Reference Id
- 1702
- Evidence Id
- 18292
- Core Evidence Id
- 18292
- Source Reference Id
- 3393
- Herb2 Reference Id
- HBREF004190
- Subject Paper Key
- HBIN021990_34428442
- Pubmed Id
- 34428442
- Doi
- 10.1016/j.bcp.2021.114742
- Paper Title
- Curcumol inhibits EBV-positive Nasopharyngeal carcinoma migration and invasion by targeting nucleolin
- Paper Abstract
- Metastasis is a major cause of recurrence and death in patients with EBV-positive Nasopharyngeal carcinoma (NPC). Previous reports documented that curcumol has both anti-cancer and anti-viral effects, but there is little literature systematically addressing the mechanism of curcumol in EBV-positive tumors. Previously we found that nucelolin (NCL) is a target protein of curcumol in CNE2 cells, an EBV-negative NPC, and in this experiment, we reported a critical role for NCL in promoting migration and invasion of C666-1 cells, an EBV-positive NPC, and found that the expression of NCL determined the level of curcumol's efficacy. Mechanistically, NCL interacted with Epstein-Barr Virus Nuclear Antigen 1 (EBNA1) to activate VEGFA/VEGFR1/PI3K/AKT signaling pathway, which in turn promoted NPC cell invasion and metastasis. Moreover, further study showed that the differential expression of NCL and curcumol intervention only had a regulatory effect on the nuclear accumulation of VEGFR1, which strengthened the anti-cancer effect of curcumol mediated through NCL. Our findings indicated that curcumol exerted anti EBV-positive NPC invasion and metastasis by downregulating EBNA1 and inhibiting VEGFA/VEGFR1/PI3K/AKT signaling by targeting NCL, which provides a novel pharmacological basis for curcumol's clinical use in treating patients with EBV-positive NPC.
- Journal
- Biochem Pharmacol
- Publish Year
- 2021
- Experiment Subject
- patient; c666-1 cells; cne2 cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Tumors; Nasopharyngeal Carcinoma
- Paper Title Cn
- Paper Title En
- Curcumol inhibits EBV-positive Nasopharyngeal carcinoma migration and invasion by targeting nucleolin
- Bilingual Status
- semi_complete