ReferenceID 1624
Oxyresveratrol inhibits human colon cancer cell migration through regulating epithelial-mesenchymal transition and microRNA
Food Funct
The major cause of death in colorectal cancer (CRC) patients is metastasis. Moreover, lots of studies have emphasized that the epithelial-mesenchymal transition (EMT) is a pivotal step in metastasis. Both transforming gr
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 1624
- Evidence Id
- 18214
- Core Evidence Id
- 18214
- Source Reference Id
- 3253
- Herb2 Reference Id
- HBREF004050
- Subject Paper Key
- HBIN021880_34664597
- Pubmed Id
- 34664597
- Doi
- 10.1039/d1fo01920a
- Paper Title
- Oxyresveratrol inhibits human colon cancer cell migration through regulating epithelial-mesenchymal transition and microRNA
- Paper Abstract
- The major cause of death in colorectal cancer (CRC) patients is metastasis. Moreover, lots of studies have emphasized that the epithelial-mesenchymal transition (EMT) is a pivotal step in metastasis. Both transforming growth factor beta (TGF-beta) and dysregulation of microRNAs (miRNAs) can induce or regulate EMT, promoting the loss of intercellular adhesion and increased motility of cancer cells. Therefore, it is necessary to prevent or inhibit the metastasis of colorectal cancer. Relatively little is known about the anti-metastatic effect of oxyresveratrol (OXY), a natural derivative of resveratrol (RES), compared to RES. Accordingly, RES was used as the positive control to investigate the effects of OXY on colon cancer cell migration. The results showed that OXY could significantly inhibit cell migration (67.17% +- 0.04, 64.89% +- 0.04) compared to RES (84.6% +- 0.07, 76.34% +- 0.08) in HCT116 cells and TGF-beta-induced HT-29 cells, respectively, via Snail/E-cadherin expression. In addition, OXY improved EMT-related miRNA expression through, for example, lowering the levels of miR-3687 and miR-301a-3p while upregulating miR-3612 in TGF-beta-induced HT-29 cells. In conclusion, OXY inhibits human colon cancer cell migration by regulating EMT and miRNAs. Based on these findings, it can be stated that OXY promotes anti-metastatic properties in CRC.
- Journal
- Food Funct
- Publish Year
- 2021
- Experiment Subject
- human; patient; hct116 cells; tgf-beta-induced ht-29 cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Colon Cancer; Cancer; Colorectal Cancer
- Paper Title Cn
- Paper Title En
- Oxyresveratrol inhibits human colon cancer cell migration through regulating epithelial-mesenchymal transition and microRNA
- Bilingual Status
- semi_complete