ReferenceID 1597
Antiobesity effects of coumestrol through expansion and activation of brown adipose tissue metabolism
J Nutr Biochem
Coumestrol is a dietary phytoestrogen with estrogen-mimicking characteristics. This study investigated the molecular mechanisms of antiobesity effects of coumestrol. Two weeks of coumestrol treatment reduced body weight
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Record Fields
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- Reference Id
- 1597
- Evidence Id
- 18187
- Core Evidence Id
- 18187
- Source Reference Id
- 3200
- Herb2 Reference Id
- HBREF003997
- Subject Paper Key
- HBIN021620_31812908
- Pubmed Id
- 31812908
- Doi
- 10.1016/j.jnutbio.2019.108300
- Paper Title
- Antiobesity effects of coumestrol through expansion and activation of brown adipose tissue metabolism
- Paper Abstract
- Coumestrol is a dietary phytoestrogen with estrogen-mimicking characteristics. This study investigated the molecular mechanisms of antiobesity effects of coumestrol. Two weeks of coumestrol treatment reduced body weight and improved glucose tolerance of high-fat diet (HFD)-fed mice. Notably, coumestrol treatment reduced adiposity but expanded brown adipose tissue mass. In addition, coumestrol treatment induced up-regulation of brown adipocyte markers and lipolytic gene expression in adipose tissue. Mechanistically, coumestrol induced an increase in mitochondrial contents of brown adipose tissue, which was associated with up-regulation of adenosine monophosphate-activated protein kinase and sirtuin 1. In vitro knockdown of estrogen receptor 1 inhibited the effect of coumestrol on brown adipogenic marker expression, increase in mitochondrial contents and oxygen consumption rate in brown adipocytes. Furthermore, lineage tracing of platelet-derived growth factor receptor A-positive (PDGFRA+) adipocyte progenitors confirmed increased levels of de novo brown adipogenesis from PDGFRA+ cells by coumestrol treatment. In conclusion, our results indicate that coumestrol has antiobesity effects through the expansion and activation of brown adipose tissue metabolism.
- Journal
- J Nutr Biochem
- Publish Year
- 2020
- Experiment Subject
- mouse; platelet-derived growth factor receptor a-positive (pdgfra+) adipocyte progenitors
- Experiment Type
- Animal Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Antiobesity effects of coumestrol through expansion and activation of brown adipose tissue metabolism
- Bilingual Status
- semi_complete