ReferenceID 1587
Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation
Pharmacol Res
Brown adipose tissue (BAT) activation or beige adipocytes in white adipocytes (WAT) (browning) is a novel strategy against obesity. Corylin, a flavonoid compound extract from Psoralea corylifolia L., has been shown to ex
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Record Fields
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- Reference Id
- 1587
- Evidence Id
- 18177
- Core Evidence Id
- 18177
- Source Reference Id
- 3184
- Herb2 Reference Id
- HBREF003981
- Subject Paper Key
- HBIN021561_33253817
- Pubmed Id
- 33253817
- Doi
- 10.1016/j.phrs.2020.105291
- Paper Title
- Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation
- Paper Abstract
- Brown adipose tissue (BAT) activation or beige adipocytes in white adipocytes (WAT) (browning) is a novel strategy against obesity. Corylin, a flavonoid compound extract from Psoralea corylifolia L., has been shown to exert anti-inflammatory, anticancer, and anti-atherosclerotic effects and ameliorate hyperlipidemia and insulin resistance. However, the therapeutic effect of corylin on obesity remains unknown. The objective of this study was to evaluate the effect of corylin on browning or obesity. Here, we report that corylin induced browning by elevating the expression levels of beige- or browning-specific marker genes, including cited1, hoxc9, pgc1alpha, prdm16, and ucp1, in 3T3-L1 adipocytes, WAT and BAT. Moreover, corylin also strikingly reduced body weight and fat accumulation and increased insulin sensitivity, mitochondrial biogenesis, and beta-oxidation in HFD- and DIO-treated mice. The browning and lipolysis effects of corylin were abolished by sirtuin 1 (SIRT1) inhibitor (EX527) and beta3-adrenergic receptor (beta3-AR) antagonist (L-748,337) treatment. The possible molecular mechanism of corylin on the browning and lipolysis of adipocytes is through SIRT1- or beta3-AR-dependent pathways. The study suggested that corylin exerts anti-obesity effects through the browning of white adipocytes, activating of BAT and promoting of lipid metabolism. Therefore, corylin may be a helpful therapeutic candidate for treating obesity.
- Journal
- Pharmacol Res
- Publish Year
- 2021
- Experiment Subject
- mouse; 3t3-l1 adipocytes
- Experiment Type
- Animal Experiment
- Phenotype Related
- Obesity; Hyperlipidemia
- Paper Title Cn
- Paper Title En
- Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation
- Bilingual Status
- semi_complete