ReferenceID 1583
Corosolic acid ameliorates non-alcoholic steatohepatitis induced by high-fat diet and carbon tetrachloride by regulating TGF-β1/Smad2, NF-κB, and AMPK signaling pathways
Phytother Res
Hawthorn (Crataegus pinnatifida Bunge. var. major) is an edible and medicinal fruit that is very common in food and traditional Chinese medicine. Corosolic acid (CA), a pentacyclic triterpenoid, which is an active compon
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Record Fields
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- Reference Id
- 1583
- Evidence Id
- 18173
- Core Evidence Id
- 18173
- Source Reference Id
- 3175
- Herb2 Reference Id
- HBREF003972
- Subject Paper Key
- HBIN021522_34213784
- Pubmed Id
- 34213784
- Doi
- 10.1002/ptr.7195
- Paper Title
- Corosolic acid ameliorates non-alcoholic steatohepatitis induced by high-fat diet and carbon tetrachloride by regulating TGF-β1/Smad2, NF-κB, and AMPK signaling pathways
- Paper Abstract
- Hawthorn (Crataegus pinnatifida Bunge. var. major) is an edible and medicinal fruit that is very common in food and traditional Chinese medicine. Corosolic acid (CA), a pentacyclic triterpenoid, which is an active component of hawthorn (Crataegus pinnatifida Bunge. var. major), has been exhibiting various pharmacological activities such as antidiabetic, antibacterial, anticancer, antiinflammatory, and antioxidant effects. The study aimed to evaluate the effect of CA on non-alcoholic steatohepatitis (NASH) in mice induced by 60 kcal% high-fat diet (HFD) and carbon tetrachloride (CCl4 ). CA lowered liver index and serum AST, ALT, TG, and TC levels compared to those in the model group. Histological analyses of the liver tissues of mice treated with CA revealed significantly decreased number of lipid droplets and alleviated inflammation and fibrosis. CA inhibited the transcripts of pro-fibrogenic markers (including alpha-SMA, collagen I, and TIMP-1) and the levels of pro-inflammatory cytokines (including TNF-alpha, IL-1beta, caspase-1, and IL-6) associated with hepatic fibrosis, and NF-kappaB translocation and TGF-beta1/Smad2 and AMPK pathways. In addition, CA reduced lipid accumulation via the regulation of AMPK and NF-kappaB activation in FFA-induced steatotic HepG2 cells. CA also decreased alpha-SMA, collagen I expressions, and Smad2 phosphorylation, which were reduced by TGF-beta1 treatment in LX2 cells. Our results suggested that CA ameliorated NASH through regulating TGF-beta1/Smad2, NF-kappaB, and AMPK signaling pathways, and CA could be developed as a potential health functional food or therapeutic agent for NASH patients.
- Journal
- Phytother Res
- Publish Year
- 2021
- Experiment Subject
- mouse; patient; ffa-induced steatotic hepg2 cells; hawthorn; lx2 cells
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Non-alcoholic Steatohepatitis; Fibrosis; Hepatic Fibrosis
- Paper Title Cn
- Paper Title En
- Corosolic acid ameliorates non-alcoholic steatohepatitis induced by high-fat diet and carbon tetrachloride by regulating TGF-β1/Smad2, NF-κB, and AMPK signaling pathways
- Bilingual Status
- semi_complete