ReferenceID 1579
Corilagin alleviates hypertrophic scars via inhibiting the transforming growth factor (TGF)-β/Smad signal pathway
Life Sci
AIMS: Exploring the effects of corilagin on hypertrophic scar (HS) and its underlying mechanisms. MAIN METHODS: Human HS-derived fibroblasts (HSFs) were isolated and treated with corilagin. To investigate the effects of
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- Reference Id
- 1579
- Evidence Id
- 18169
- Core Evidence Id
- 18169
- Source Reference Id
- 3166
- Herb2 Reference Id
- HBREF003963
- Subject Paper Key
- HBIN021473_33862115
- Pubmed Id
- 33862115
- Doi
- 10.1016/j.lfs.2021.119483
- Paper Title
- Corilagin alleviates hypertrophic scars via inhibiting the transforming growth factor (TGF)-β/Smad signal pathway
- Paper Abstract
- AIMS: Exploring the effects of corilagin on hypertrophic scar (HS) and its underlying mechanisms. MAIN METHODS: Human HS-derived fibroblasts (HSFs) were isolated and treated with corilagin. To investigate the effects of corilagin on HSFs, quantitative real time polymerase chain reaction (qRT-PCR), western blotting, wound healing, and immunofluorescence assays were performed. These effects were confirmed in a rabbit ear scar model by histological and immunohistochemical studies. Lastly, western blot assay was performed to detect the protein levels of several components of the transforming growth factor (TGF)-beta/Smad signaling pathway, as well as the protein levels of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs). KEY FINDINGS: Corilagin showed multiple effects on HSFs, including does-dependent inhibition of collagen production, cell proliferation, and migration, besides suppression of the activation of HSFs. Moreover, corilagin suppressed HS formation and collagen deposition in a rabbit ear scar model. Corilagin also inhibited fibroblast proliferation and alpha-smooth muscle actin (alpha-SMA) expression in vivo. Finally, western blot analysis revealed that corilagin downregulated the protein levels of TGF-beta1 and TGF-beta receptor type I (TGFbetaRI), thus lowering the level of p-smad2/3, also affected the protein levels of MMPs and TIMP1. SIGNIFICANCE: Corilagin could be a potential agent for HS treatment through the inhibition of extracellular matrix (ECM) deposition and multiple functions of fibroblasts.
- Journal
- Life Sci
- Publish Year
- 2021
- Experiment Subject
- human; human hs-derived fibroblasts; rabbit
- Experiment Type
- Cell Experiment
- Phenotype Related
- Hypertrophic Scar
- Paper Title Cn
- Paper Title En
- Corilagin alleviates hypertrophic scars via inhibiting the transforming growth factor (TGF)-β/Smad signal pathway
- Bilingual Status
- semi_complete