ReferenceID 1553
Cirsilineol inhibits proliferation of lung squamous cell carcinoma by inducing ROS mediated apoptosis
Food Chem Toxicol
Cirsilineol belonging to the flavones category have not been explored in detail for anti-proliferative potential, therefore selected for the investigation. Hence, the antiproliferative potential of cirsilineol has been e
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Record Fields
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- Reference Id
- 1553
- Evidence Id
- 18143
- Core Evidence Id
- 18143
- Source Reference Id
- 3103
- Herb2 Reference Id
- HBREF003900
- Subject Paper Key
- HBIN020707_32640357
- Pubmed Id
- 32640357
- Doi
- 10.1016/j.fct.2020.111550
- Paper Title
- Cirsilineol inhibits proliferation of lung squamous cell carcinoma by inducing ROS mediated apoptosis
- Paper Abstract
- Cirsilineol belonging to the flavones category have not been explored in detail for anti-proliferative potential, therefore selected for the investigation. Hence, the antiproliferative potential of cirsilineol has been established in NCIH-520 cells. Cirsilineol exhibited good binding-energy and inhibited the activity of ODC, CATD, DHFR, HYAL, LOX-5, and COX-2 up to 45.14% at 100 muM. It significantly inhibited the proliferation of NCIH-520 cells (81.96%) and likewise, the proliferation of other cell lines up to 48.50%. It also induced an increase in the sub-diploid cell population, which then leads to an increase in apoptosis by 2.64 and 5.12 fold at 10 muM and 100 muM respectively. Further, the Annexin-V-FITC assay confirmed the late apoptosis and necrosis in the NCIH-520 cell line induced by cirsilineol. The ROS production was enhanced by 1.16 and 2.22 folds at 10 muM and 100 muM respectively. Besides, cirsilineol revealed acceptable ADME properties, non-toxic and non-mutagenic compound. Altogether, these findings provide evidence that cirsilineol inhibited the proliferation of NCIH-520 cells by inducing ROS-mediated apoptosis and offer new insight into the anti-proliferative potential of cirsilineol, which can further be exploited to either synthesise new derivatives or its candid usage as a herbal lead for cancer treatment.
- Journal
- Food Chem Toxicol
- Publish Year
- 2020
- Experiment Subject
- Experiment Type
- Cell Experiment
- Phenotype Related
- Cancer
- Paper Title Cn
- Paper Title En
- Cirsilineol inhibits proliferation of lung squamous cell carcinoma by inducing ROS mediated apoptosis
- Bilingual Status
- semi_complete