ReferenceID 1483
Carnosol suppresses RANKL-induced osteoclastogenesis and attenuates titanium particles-induced osteolysis
J Cell Physiol
Osteolysis is a common medical condition characterized by excessive activity of osteoclasts and bone resorption, leading to severe poor quality of life. It is essential to identify the medications that can effectively su
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Record Fields
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- Reference Id
- 1483
- Evidence Id
- 18073
- Core Evidence Id
- 18073
- Source Reference Id
- 2979
- Herb2 Reference Id
- HBREF003776
- Subject Paper Key
- HBIN019759_32722851
- Pubmed Id
- 32722851
- Doi
- 10.1002/jcp.29978
- Paper Title
- Carnosol suppresses RANKL-induced osteoclastogenesis and attenuates titanium particles-induced osteolysis
- Paper Abstract
- Osteolysis is a common medical condition characterized by excessive activity of osteoclasts and bone resorption, leading to severe poor quality of life. It is essential to identify the medications that can effectively suppress the excessive differentiation and function of osteoclasts to prevent and reduce the osteolytic conditions. It has been reported that Carnosol (Car), isolated from rosemary and salvia, has anti-inflammatory, antioxidative, and anticancer effects, but its activity on osteolysis has not been determined. In this study, we found that Car has a strong inhibitory effect on the receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast differentiation dose-dependently without any observable cytotoxicity. Moreover, Car can inhibit the RANKL-induced osteoclastogenesis and resorptive function via suppressing NFATc1, which is a result of affecting MAPK, NF-kappaB and Ca2+ signaling pathways. Moreover, the particle-induced osteolysis mouse model confirmed that Car could be effective for the treatment of bone loss in vivo. Taken together, by suppressing the formation and function of RANKL-induced osteoclast, Car, may be a therapeutic supplementary in the prevention or the treatment of osteolysis.
- Journal
- J Cell Physiol
- Publish Year
- 2021
- Experiment Subject
- mouse
- Experiment Type
- Cell Experiment
- Phenotype Related
- Osteolysis; Bone Loss
- Paper Title Cn
- Paper Title En
- Carnosol suppresses RANKL-induced osteoclastogenesis and attenuates titanium particles-induced osteolysis
- Bilingual Status
- semi_complete