ReferenceID 1378
Butein inhibits lipogenesis in Caenorhabditis elegans
Biofactors
Butein, a flavonoid found in annatto seeds and lacquer trees, may be used for many health benefits, including the prevention of obesity. However, its anti-obesity effects are not completely understood; in particular, the
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Record Fields
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- Reference Id
- 1378
- Evidence Id
- 17968
- Core Evidence Id
- 17968
- Source Reference Id
- 2770
- Herb2 Reference Id
- HBREF003567
- Subject Paper Key
- HBIN019083_32663368
- Pubmed Id
- 32663368
- Doi
- 10.1002/biof.1667
- Paper Title
- Butein inhibits lipogenesis in Caenorhabditis elegans
- Paper Abstract
- Butein, a flavonoid found in annatto seeds and lacquer trees, may be used for many health benefits, including the prevention of obesity. However, its anti-obesity effects are not completely understood; in particular, the effects of butein on the regulation of lipid metabolism have not been explained. Thus, the goal of the current study was to determine the effects of butein on lipid metabolism in Caenorhabditis elegans, which is a multi-organ nematode used as an animal model in obesity research. Butein at 70 muM reduced triglyceride content by 27% compared to the control without altering food intake and energy expenditure. The reduced triglyceride content by butein was associated with the downregulation of sbp-1, fasn-1, and fat-7, the lipogenesis-related homologs of sterol regulatory element-binding proteins, fatty acid synthase and stearoyl-CoA desaturase, respectively. Furthermore, fat-7 and skn-1, a homolog of nuclear respiratory factors, were identified as genetic requirements for butein's effects on triglyceride content in C. elegans. The effects of butein on sbp-1 and fasn-1 were dependent on skn-1, but the downregulation of fat-7 was independent of skn-1. These results suggest that the inhibitory effects of butein on lipogenesis are via SKN-1- and FAT-7-dependent pathways in C. elegans.
- Journal
- Biofactors
- Publish Year
- 2020
- Experiment Subject
- Experiment Type
- Animal Experiment
- Phenotype Related
- Obesity
- Paper Title Cn
- Paper Title En
- Butein inhibits lipogenesis in Caenorhabditis elegans
- Bilingual Status
- semi_complete