ReferenceID 1370
Brusatol Inhibits Tumor Growth and Increases the Efficacy of Cabergoline against Pituitary Adenomas
Oxid Med Cell Longev
Cabergoline (CAB) is the first choice for treatment of prolactinoma and the most common subtype of pituitary adenoma. However, drug resistance and lack of effectiveness in other pituitary tumor types remain clinical chal
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Record Fields
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- Reference Id
- 1370
- Evidence Id
- 17960
- Core Evidence Id
- 17960
- Source Reference Id
- 2757
- Herb2 Reference Id
- HBREF003554
- Subject Paper Key
- HBIN018930_34221237
- Pubmed Id
- 34221237
- Doi
- 10.1155/2021/6696015
- Paper Title
- Brusatol Inhibits Tumor Growth and Increases the Efficacy of Cabergoline against Pituitary Adenomas
- Paper Abstract
- Cabergoline (CAB) is the first choice for treatment of prolactinoma and the most common subtype of pituitary adenoma. However, drug resistance and lack of effectiveness in other pituitary tumor types remain clinical challenges to this treatment. Brusatol (BT) is known to inhibit cell growth and promote apoptosis in a variety of cancer cells. In our present studies, we investigate the effects of BT on pituitary tumor cell proliferation in vitro and in vivo. BT treatment resulted in an increase in Annexin V-expressing cells and promoted the expression of apoptosis-related proteins in rat and human pituitary tumor cells. Investigation of the mechanism underlying this effect revealed that BT increased the production of reactive oxygen species (ROS) and inhibited the phosphorylation of 4EBP1 and S6K1. Furthermore, treatment with a combination of BT and CAB resulted in greater antitumor effects than either treatment alone in nude mice and pituitary tumor cells. Collectively, our results suggest that the BT-induced ROS accumulation and inhibition of mTORC1 signaling pathway leads to inhibition of tumor growth. Combined use of CAB and BT may increase the clinical effectiveness of treatment for human pituitary adenomas.
- Journal
- Oxid Med Cell Longev
- Publish Year
- 2021
- Experiment Subject
- mouse; rat; human; annexin v-expressing cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Cabergoline; Pituitary Adenoma; Tumor; Prolactinoma; Pituitary Adenomas; Pituitary Tumor; Cancer
- Paper Title Cn
- Paper Title En
- Brusatol Inhibits Tumor Growth and Increases the Efficacy of Cabergoline against Pituitary Adenomas
- Bilingual Status
- semi_complete