ReferenceID 1369
Pharmacological investigation of brucine anti-ulcer potential
Front Pharmacol
Gastric ulcer is one of the most common chronic gastrointestinal diseases characterized by a significant defect in the mucosal barrier. The current study has been conducted to evaluate the brucine anti-ulcer effect. Bruc
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- Reference Id
- 1369
- Evidence Id
- 17959
- Core Evidence Id
- 17959
- Source Reference Id
- 2754
- Herb2 Reference Id
- HBREF003551
- Subject Paper Key
- HBIN018923_36059979
- Pubmed Id
- 36059979
- Doi
- 10.3389/fphar.2022.886433
- Paper Title
- Pharmacological investigation of brucine anti-ulcer potential
- Paper Abstract
- Gastric ulcer is one of the most common chronic gastrointestinal diseases characterized by a significant defect in the mucosal barrier. The current study has been conducted to evaluate the brucine anti-ulcer effect. Brucine has binding energy values ranging from -2.99 to -8.11 kcal/mol against chosen targets, according to in silico research. Brucine exhibits an inhibitory effect against Helicobacter pylori . In vivo findings revealed that brucine (3 mg/kg) showed effective results in healing ethanol-induced ulcer lesions of the gastric region in rats. Brucine showed an inhibitory effect against H + /K + -ATPase. Levels of glutathione, glutathione-s-transferase, and catalase were enhanced in the gastric rat tissue with the use of brucine, while a significant decrease in lipid peroxide levels was seen. Histopathological evaluation showed improvement in cellular architecture and a decrease in inflammatory indicators like cyclooxygenase, tumor necrosis factor, and nuclear factor kappa B expression, validated through immunohistochemistry, enzyme-linked immunosorbent assay, and Western blot techniques. In the reverse transcription-polymerase chain reaction, brucine decreased H + /K + -ATPase mRNA levels. This study reveals that brucine possesses stable binding affinities against selected targets. Brucine exhibits an anti-ulcer effect, mediated via anti- H. pylori , H + /K + -ATPase inhibition, and antioxidant and anti-inflammatory pathways.
- Journal
- Front Pharmacol
- Publish Year
- 2022
- Experiment Subject
- rat
- Experiment Type
- Animal Experiment
- Phenotype Related
- Chronic Gastrointestinal Diseases; Ethanol-induced Ulcer Lesions; Gastric Ulcer; Tumor
- Paper Title Cn
- Paper Title En
- Pharmacological investigation of brucine anti-ulcer potential
- Bilingual Status
- semi_complete