ReferenceID 1360
Inhibitory effects of biochanin A on titanium particle-induced osteoclast activation and inflammatory bone resorption via NF-κB and MAPK pathways
J Cell Physiol
Revision operations have become a new issue after successful artificial joint replacements, and periprosthetic osteolysis leading to prosthetic loosening is the main cause of why the overactivation of osteoclasts (OCs) p
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Record Fields
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- Reference Id
- 1360
- Evidence Id
- 17950
- Core Evidence Id
- 17950
- Source Reference Id
- 2728
- Herb2 Reference Id
- HBREF003525
- Subject Paper Key
- HBIN018523_32853427
- Pubmed Id
- 32853427
- Doi
- 10.1002/jcp.29948
- Paper Title
- Inhibitory effects of biochanin A on titanium particle-induced osteoclast activation and inflammatory bone resorption via NF-κB and MAPK pathways
- Paper Abstract
- Revision operations have become a new issue after successful artificial joint replacements, and periprosthetic osteolysis leading to prosthetic loosening is the main cause of why the overactivation of osteoclasts (OCs) plays an important role. The effect of biochanin A (BCA) has been examined in osteoporosis, but no study on the role of BCA in prosthetic loosening osteolysis has been conducted yet. In this study, we utilised enzyme-linked immunosorbent assay, computed tomography imaging, and histological analysis. Results showed that BCA downregulated the secretion levels of tumor necrosis factor-alpha, interleukin-1alpha (IL-1alpha), and IL-1beta to suppress inflammatory responses. The secretion levels of receptor-activated nuclear factor-kappaB ligand, CTX-1, and osteoclast-associated receptor as well as Ti-induced osteolysis were also reduced. BCA effectively inhibited osteoclastogenesis and suppressed hydroxyapatite resorption by downregulating OC-related genes in vitro. Analysis of mechanisms indicated that BCA inhibited the signalling pathways of mitogen-activated protein kinase (P38, extracellular signal-regulated kinase, and c-JUN N-terminal kinase) and nuclear factor-kappaB (inhibitor kappaB-alpha and P65), thereby downregulating the expression of nuclear factor of activated T cell 1 and c-Fos. In conclusion, BCA may be an alternative choice for the prevention of prosthetic loosening caused by OCs.
- Journal
- J Cell Physiol
- Publish Year
- 2021
- Experiment Subject
- Experiment Type
- Cell Experiment
- Phenotype Related
- Osteoporosis; Tumor; Ti-induced Osteolysis; Prosthetic Loosening; Prosthetic Loosening Osteolysis; Periprosthetic Osteolysis
- Paper Title Cn
- Paper Title En
- Inhibitory effects of biochanin A on titanium particle-induced osteoclast activation and inflammatory bone resorption via NF-κB and MAPK pathways
- Bilingual Status
- semi_complete