ReferenceID 1350
Bergenin ameliorates airway inflammation and remodeling in asthma by activating SIRT1 in macrophages to regulate the NF-κB pathway
Front Pharmacol
Airway inflammation and remodeling are critical pathological changes in asthma, and macrophage activation plays a vital role in this process. Sirtuin 1 (SIRT1) reduces airway inflammation by affecting macrophages in asth
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Record Fields
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- Reference Id
- 1350
- Evidence Id
- 17940
- Core Evidence Id
- 17940
- Source Reference Id
- 2699
- Herb2 Reference Id
- HBREF003496
- Subject Paper Key
- HBIN017919_36313381
- Pubmed Id
- 36313381
- Doi
- 10.3389/fphar.2022.994878
- Paper Title
- Bergenin ameliorates airway inflammation and remodeling in asthma by activating SIRT1 in macrophages to regulate the NF-κB pathway
- Paper Abstract
- Airway inflammation and remodeling are critical pathological changes in asthma, and macrophage activation plays a vital role in this process. Sirtuin 1 (SIRT1) reduces airway inflammation by affecting macrophages in asthma. This study aimed to investigate the potential benefit and underlying mechanism of the SIRT1 agonist bergenin as a treatment for asthma. We performed in vivo and in vitro experiments by establishing a Sirt1 fl/fl -LysMcre mouse asthma model and using the alveolar macrophage-like cell line MH-S, respectively. Our results show that Sirt1 fl/fl -LysMcre asthmatic mice exhibited more severe airway inflammation and airway remodeling than wild-type mice. As an activator of SIRT1, bergenin attenuated asthmatic airway pathology and reduced production of interleukins 1β, IL-5, IL-6, and matrix metalloproteinase 9 (MMP-9) in wild-type asthmatic mice. However, the therapeutic effects of bergenin were significantly attenuated in Sirt1 fl/fl -LysMcre asthmatic mice or following coadministration with the SIRT1 inhibitor EX-527. Further experiments showed that activation of SIRT1 by bergenin deacetylates nuclear factor κB and hinders its nuclear translocation, thereby affecting IL-1β, IL-5, IL-6, and MMP-9 production by regulating transcriptional activity. Our study suggests that bergenin can improve asthma-induced airway inflammation and remodeling by activating SIRT1 in macrophages.
- Journal
- Front Pharmacol
- Publish Year
- 2022
- Experiment Subject
- mouse; alveolar macrophage-like cell line mh-s
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Asthma; Asthma-induced Airway Inflammation; Airway Inflammation
- Paper Title Cn
- Paper Title En
- Bergenin ameliorates airway inflammation and remodeling in asthma by activating SIRT1 in macrophages to regulate the NF-κB pathway
- Bilingual Status
- semi_complete