ReferenceID 1347
Bergenin as a Novel Urate-Lowering Therapeutic Strategy for Hyperuricemia
Front Cell Dev Biol
Bergenin is a C-glucoside of 4-O-methyl gallic acid isolated from several medicinal plants and has multiple biological activities. The aim of this study was to assess the potential usefulness of bergenin in hyperuricemia
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- Reference Id
- 1347
- Evidence Id
- 17937
- Core Evidence Id
- 17937
- Source Reference Id
- 2694
- Herb2 Reference Id
- HBREF003491
- Subject Paper Key
- HBIN017919_32850823
- Pubmed Id
- 32850823
- Doi
- 10.3389/fcell.2020.00703
- Paper Title
- Bergenin as a Novel Urate-Lowering Therapeutic Strategy for Hyperuricemia
- Paper Abstract
- Bergenin is a C-glucoside of 4-O-methyl gallic acid isolated from several medicinal plants and has multiple biological activities. The aim of this study was to assess the potential usefulness of bergenin in hyperuricemia. We found that bergenin reduced serum urate levels in hyperuricemia mice by promoting renal and gut uric acid excretion. Bergenin treatment increased Abcg2 expression both in the kidneys and intestine, while the expression of Slc2a9 was suppressed in the kidney and increased in the intestine. Moreover, bergenin induced ABCG2 expression in HK-2 and Caco-2 cells, as well as SLC2A9 in Caco-2 cells, via the activation of PPARgamma. Nevertheless, bergenin suppressed SLC2A9 expression in HK-2 cells by inhibiting the nuclear translocation of p53. Furthermore, bergenin decreased the serum levels of IL-6, IL-1beta, and TNF-alpha in hyperuricemia mice, and promoted a polarization shift from the M1 to M2 phenotype in RAW264.7 cells. In conclusion, these findings provide evidence supporting the further development of bergenin as a novel therapeutic strategy for hyperuricemia.
- Journal
- Front Cell Dev Biol
- Publish Year
- 2020
- Experiment Subject
- mouse; caco-2 cells; hk-2 cells; raw264.7 cells
- Experiment Type
- Animal Experiment
- Phenotype Related
- Hyperuricemia
- Paper Title Cn
- Paper Title En
- Bergenin as a Novel Urate-Lowering Therapeutic Strategy for Hyperuricemia
- Bilingual Status
- semi_complete